Next Article in Journal
Relaxant Effect of the Ethanol Extract of Helichrysum plicatum (Asteraceae) on Isolated Rat Ileum Contractions
Previous Article in Journal
Probing the Dynamics of Solvation and Structure of the OH- Ion in Aqueous Solution from Picosecond Transient Absorption Measurements
Article

In Vitro and in Vivo Effects of Laurus nobilis L. Leaf Extracts

Department of Chemistry, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(5), 3378-3390; https://doi.org/10.3390/molecules15053378
Received: 24 March 2010 / Revised: 28 April 2010 / Accepted: 5 May 2010 / Published: 7 May 2010
The in vitro and in vivo antioxidant activities of different extracts of laurel leaves were studied. Free radical scavenging capacity (RSC) was evaluated measuring the scavenging activity on the DPPH, NO, O2·- and OH radicals. The effects on lipid peroxidation (LP) were also evaluated. Experimental results indicate that ethyl acetate extract of leaves has exhibited the largest RSC capacity in neutralization of DPPH, NO, O2·- and OH radicals. The same result was obtained in investigation of extracts impact on LP. The in vivo effects were evaluated on some antioxidant systems (activities of GSHPx, LPx, Px, CAT and XOD, and GSH content) in the mice liver and blood-hemolysate after treatment with the examined laurel extracts, or in combination with carbon tetrachloride (CCl4). On the basis of the results obtained it can be concluded that the examined extracts exhibited a certain protective effect, which is more pronounced on the liver than on blood-hemolysate parameters. The results obtained indicate toxicity of CCl4, probably due to the radicals involved in its metabolism. Combined treatments with CCl4 and the examined extracts showed both positive and negative synergism. Based on the experimental results, the strongest protective effect was shown by the EtOAc extract. View Full-Text
Keywords: Laurus nobilis L.; extracts; free radicals; in vitro experiments; biochemical parameters Laurus nobilis L.; extracts; free radicals; in vitro experiments; biochemical parameters
MDPI and ACS Style

Kaurinovic, B.; Popovic, M.; Vlaisavljevic, S. In Vitro and in Vivo Effects of Laurus nobilis L. Leaf Extracts. Molecules 2010, 15, 3378-3390. https://doi.org/10.3390/molecules15053378

AMA Style

Kaurinovic B, Popovic M, Vlaisavljevic S. In Vitro and in Vivo Effects of Laurus nobilis L. Leaf Extracts. Molecules. 2010; 15(5):3378-3390. https://doi.org/10.3390/molecules15053378

Chicago/Turabian Style

Kaurinovic, Biljana, Mira Popovic, and Sanja Vlaisavljevic. 2010. "In Vitro and in Vivo Effects of Laurus nobilis L. Leaf Extracts" Molecules 15, no. 5: 3378-3390. https://doi.org/10.3390/molecules15053378

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop