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Article

Selective Heck Arylation of Cyclohexene with Homogeneous and Heterogeneous Palladium Catalysts

by
Ewa Mieczyńska
and
Anna M. Trzeciak
*
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(4), 2166-2177; https://doi.org/10.3390/molecules15042166
Submission received: 27 January 2010 / Revised: 10 March 2010 / Accepted: 23 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Heck Coupling)
Browse Figures
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Abstract

:
Palladium catalysts containing Pd(II) supported on Al2O3 and alumina-based mixed oxides, Al2O3-ZrO2, Al2O3-CeO2, and Al2O3-Fe2O3, are very effective in the Heck coupling of iodobenzene with cyclohexene in DMF solution. The best results, up to 81% of monoarylated products with a selectivity to 4-phenylcyclohexene (3) close to 90% were obtained with KOH as a base. The catalytic activity of palladium supported on alumina-based oxides was compared with that of homogeneous precursors, such as Pd(OAc)2 and PdCl2(PhCN)2, used in [Bu4N]Br as the reaction medium. Under such conditions homogeneous systems were more selective and produced up to 60% of monoarylated products with a selectivity to 3 close to 60%.

Graphical Abstract

1. Introduction

The Heck coupling, a C–C bond formation process also described as olefin arylation, is one of the most important palladium-catalyzed reactions [1,2,3,4,5,6]. Arylated olefins, the final products of the Heck reaction, have very broad application in the synthesis of pharmaceuticals, agrochemicals, and natural products. Therefore, very intensive research has been addressed to the development of new, simple and efficient catalytic systems for the Heck coupling.
Typical palladium catalysts for the Heck reaction contain phosphines; however, recently, phosphine-free catalytic systems, economical and environmentally friendly, have been receiving increasing attention [7,8,9,10,11,12,13,14,15,16].
It seems most likely that in phosphine-free systems a key role is played by Pd(0) nanoparticles formed in situ from Pd(II) precursors [4,9,14,15]. However, in the absence of any stabilizing agents such catalysts can be deactivated as a result of the formation of inactive “palladium black”. Tetraalkylammonium salts or inorganic supports are known as good stabilizers of palladium, often used in catalytic systems to prevent their deactivation [8,11,17,18,19,20].
There are also many examples of application in Heck coupling of palladium supported on inorganic oxides of Al, Ti, Zn, Zr, Mg [21,22,23,24,25,26], on silica [27,28] as well on zeolites [29,30]. In most cases reactions of aryl halides with acrylates, acrylonitrile, styrene or terminal alkenes were studied [31]. Mechanistic studies performed in these systems led to the conclusion that the main catalytic role is played by soluble palladium species formed as a result of leaching from the support and re-adsorbed in the end of the catalytic process [32].
The Heck reaction of cyclic olefins, like cyclohexene, cyclopentene, or 2,3-dihydrofuran, present an attractive pathway to create molecules containing stereogenic centers [20,33,34,35,36,37,38,39,40]. The difficulty of these reactions has to do with their regioselectivity, because a mixture of different products, mono- and diarylated olefins, is always formed. Studies of the Heck coupling of cyclohexene with 4-bromoacetophenone have revealed the high catalytic activity of soluble palladium species, such as palladacycles or Pd(OAc)2/PPh3, which produce 89% and 79% of monoarylated olefins. Surprisingly only very few reports deal with application of heterogeneous systems in Heck coupling of cycloalkenes. For example, different heterogeneous palladium catalysts, i.e. Pd/C, Pd/SiO2, Pd/MgO, Pd/Al2O3, have been used in Heck coupling of 4-bromoacetopheneone with cyclohexene and cyclo-pentene [33]. In contrast to homogeneous systems, heterogeneous catalysts were active not only in the Heck coupling but also in dehalogenation of the substrate leading to the formation of acetophenone as the predominant product [33].
In this paper, we present the results of our studies on the Heck coupling of iodobenzene with cyclohexene performed in homogeneous and heterogeneous phosphine-free systems. We chose palladium supported on alumina-based oxides as heterogeneous catalysts which shown already good catalytic performance in other cross-coupling reactions [41,42].

2. Results and Discussion

2.1. Homogeneous catalysts

The Heck reaction of cyclohexene with iodobenzene is presented on Figure 1. According to literature data, three monoarylated products, 1, 2, and 3, may be formed, with 4-phenylcyclohexene (3) being the most thermodynamically stable [33]. Besides monoarylated products, diarylated ones can also be formed, and Figure 2 shows their five possible isomers.
Molecules 15 02166 g001 550
Figure 1. The Heck reaction of cyclohexene with iodobenzene.
Figure 1. The Heck reaction of cyclohexene with iodobenzene.
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Figure 2. Diarylated products formed in the Heck reaction of cyclohexene with iodobenzene.
Figure 2. Diarylated products formed in the Heck reaction of cyclohexene with iodobenzene.
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Two palladium complexes, Pd(OAc)2 and PdCl2(PhCN)2, were tested in the Heck reaction under selected reaction conditions (140 ºC, 4 h) in DMF as solvent and produced less than 15% of products. The most plausible explanation for such low activity is a fast deactivation of the catalyst caused by its reduction to palladium black. The successful Heck coupling procedures of cycloalkenes with aryl halides reported up to now consisted in application of phosphorus ligands, preventing formation of inactive black palladium [33,34,35,36,37,38,39,40]. Therefore, in subsequent experiments molten [Bu4N]Br was used as the reaction medium. A positive effect of tetrabutylammonium salt was demonstrated earlier in other palladium catalyzed systems [11,20,43] and it was expected that also in the studied systems [Bu4N]Br would stabilize reduced palladium species (i.e. nanoparticles) formed in situ.
Figure 3 and Figure 4 present the correlations between the total yield of the Heck reaction and the amount of palladium for both of the systems studied. Characteristically, in a case of Pd(OAc)2 the dependence was non-linear: the yield increased with an increase in the amount of palladium and then decreased. This type of concentration dependence had been observed earlier in other Heck reactions and interpreted as an indication of the participation of Pd(0) nanoparticles in the reaction course [44]. The formation of Pd(0) nanoparticles can be considered in the systems studied in agreement with XPS results that shown, that when PdCl2(PhCN)2 reacted with NaHCO3 in the presence of [Bu4N]Br ca. 50% of palladium was reduced to Pd(0) [22]. Most probably, Pd(0) nanoparticles stabilized by [Bu4N]Br were formed, similar to these described for Pd-chitosan nanocomposite [45]. In the presence of [Bu4N]Br and PhI palladium nanoparticles are dissolved forming soluble complexes of Pd(II), also catalytically active. A special role in the catalytic process is played by soluble complexes containing aryl ligands, e.g. [Bu4N]2[Pd(Ar)X3], key intermediates in the catalytic cycle [8].
Molecules 15 02166 g003 550
Figure 3. The yield of mono- and diarylated cyclohexenes obtained in the Heck reaction catalyzed by Pd(OAc)2 in [Bu4N]Br (140 ºC, 4 h, NaHCO3).
Figure 3. The yield of mono- and diarylated cyclohexenes obtained in the Heck reaction catalyzed by Pd(OAc)2 in [Bu4N]Br (140 ºC, 4 h, NaHCO3).
Molecules 15 02166 g003
Molecules 15 02166 g004 550
Figure 4. The yield of mono- and diarylated cyclohexenes obtained in the Heck reaction catalyzed by PdCl2(PhCN)2 in [Bu4N]Br (140 ºC, 4 h, NaHCO3).
Figure 4. The yield of mono- and diarylated cyclohexenes obtained in the Heck reaction catalyzed by PdCl2(PhCN)2 in [Bu4N]Br (140 ºC, 4 h, NaHCO3).
Molecules 15 02166 g004
From the dependences shown in Figure 3 and Figure 4, it is possible to estimate the optimal range of the palladium amount in both systems. For Pd(OAc)2, the highest yields of coupling products were obtained when the amount of palladium was 0.35–0.39% mol. For PdCl2(PhCN)2, the range of applicability was wider, 0.30–0.78% mol, and an effect of the amount of palladium was less significant.
The yield of monoarylated products was similar for both catalysts, the maximum being 60% and the average amount of diarylated products being ca. 18%. In Table 1 there are collected results illustrating an effect of base on the reaction yield and selectivity. In the presence of NaOAc the yield of diarylated products increased to ca. 30%, whereas amount of monoarylated cyclohexenes reminded close to 50%. When KOH was used as a base 60–67% of monoarylated products were formed. As expected, product 3 was the main one in the fraction of monoarylated cyclohexenes and the highest selectivity to 3 was noted for KOH as a base.
Table
Table 1. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd(OAc)2 and PdCl2(PhCN)2 in [Bu4N]Br.
Table 1. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd(OAc)2 and PdCl2(PhCN)2 in [Bu4N]Br.
CatalystBasePhI conversion (%)Yield
1+2+3
(%)		Selectivity 1:2:3 Yield
4+5+6+7+8
(%)		Biphenyl
(%)
Pd(OAc)2NaHCO3745516:20:64164
NaOAc905317:21:62279
KOH1006713:3:842310
PdCl2(PhCN)2NaHCO3815319:19:621711
NaOAc885318:28:543015
KOH1006015:5:802020
Reaction conditions: 2.68 × 10-3 mol of PhI, 8.77 × 10-3 mol of cyclohexene, 0.53% mol Pd, 2.5 × 10-3 mol of NaHCO3, 5 cm3 of DMF or 2.3 × 10-3 mol of [Bu4N]Br, 140 ºC, 4 h.

2.2. Heterogeneous catalysts

For further studies, we selected heterogenized palladium catalysts obtained by impregnation of PdCl2 on alumina-based oxides. Alumina and three different alumina-based oxides containing 10% of ZrO2, or Fe2O3 or 2% of CeO2, were used as supports. The presence of the second metal oxide modifies the physicochemical properties of alumina, which can influence the catalytic activity. For example, an effect of CeO2 on acid-base properties of alumina was observed [46] and an increase of the hydrothermal stability of mixed Al2O3-ZrO2 oxides was noted [47,48]. It was also expected, that application of four different alumina-based oxides as supports for palladium catalysts would allow to formulate some more general conclusions about the catalytic activity of heterogeneous systems in the arylation of cyclohexene.
First, the effect of the solvent was studied for one selected catalyst, Pd/Al2O3 + CeO2, at different palladium concentrations (Table 2). When the amount of palladium increased from 0.26% mol to 0.35% mol, both the conversion of iodobenzene and the yield of monoarylated products 1–3 increased in DMF as solvent. The maximum yield of products 1–3 was 46% with selectivity to 3 of 74%. In these reactions, the yield of diarylated olefins and biphenyl remained at a similar level, 4–9%. When instead of DMF molten [Bu4N]Br was used as the reaction medium, the conversion increased to 79–91%, but selectivity decreased remarkably. The monoarylated products were obtained with a yield of ca. 40%, whereas the amount of diarylated olefins increased to ca. 30% and that of biphenyl to 16%. It is interesting to note that selectivity in the fraction of monoarylated products also changed and product 2 became the main one, whereas 3 predominated in reactions performed in DMF.
In agreement with earlier results an intensive leaching of palladium from the support can be proposed for the catalytic system in [Bu4N]Br, leading to formation of anionic species of the type [Bu4N]2[PdX4], similar to these present in a homogeneous system. However, the different composition of final products of Heck coupling formed with homogeneous and heterogeneous palladium precursors in tetrabutylammonium salt can indicate that supported palladium is also involved in the reaction course. XRD and TEM analyses of one selected catalyst Pd/Al2O3-Fe2O3 performed after Heck reaction confirmed the presence of Pd(0) nanoparticles of diameter ca. 17 nm (XRD) or 15–50 nm (TEM) (Figure 5 and Figure 6).
Molecules 15 02166 g005 550
Figure 5. XRD pattern of Al2O3-Fe2O3 support and Pd/Al2O3-Fe2O3 after Heck reaction.
Figure 5. XRD pattern of Al2O3-Fe2O3 support and Pd/Al2O3-Fe2O3 after Heck reaction.
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Molecules 15 02166 g006 550
Figure 6. TEM of the Pd/Al2O3-Fe2O3 after Heck reaction.
Figure 6. TEM of the Pd/Al2O3-Fe2O3 after Heck reaction.
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The effect of PPh3 on the Heck coupling was also studied for comparison; however, it can be described as an inhibiting one, lowering the yield of monoarylated products (Table 1). Such an inhibiting effect can be explained to some extent by the reducing properties of PPh3. However PPh3 can also occupy active sites on the surface of the catalyst making it less accessible for coordination of reactants.
Table
Table 2. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd/Al2O3+CeO2 in DMF and in [Bu4N]Br.
Table 2. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd/Al2O3+CeO2 in DMF and in [Bu4N]Br.
Pd% molSolvent[PPh3]:[Pd] PhI conversion (%)Yield
1+2+3
(%)		Selectivity 1:2:3 Yield
4+5+6+7+8
(%)		Biphenyl
(%)
0.26DMF 393116:13:7145
0.26[Bu4N]Br 793216:47:383115
0.35DMF 433315:12:7356
0.35[Bu4N]Br 914513:49:383016
0.53DMF 644214:10:761012
0.53[Bu4N]Br 854013:57:392916
0.35DMF5271718:12:7045
0.35DMF10322218:5:7745
Reaction conditions: 2.68 × 10-3 mol of PhI, 8.77 × 10-3 mol of cyclohexene, 2.5 × 10-3 mol of NaHCO3, 5 cm3 of DMF or 2.3 × 10-3 mol of [Bu4N]Br, 140 ºC, 4 h.
Further studies were continued in DMF as a solvent offering a higher selectivity in Heck coupling. Four palladium catalysts supported on different mixed-oxides used without any additives, produced up to 50% of monoarylated products. To check whether any improvement of selectivity was possible, different bases were tested for the catalyst Pd/Al2O3 (Table 3). With Cs2CO3 and K2CO3, an increase in biphenyl yield was noted, even up to 29%. Much better results were found when KOH or NaOH was used, KOH being superior to NaOH if the total yield of monoarylated cyclohexenes and selectivity to product 3 are taken into account. A similar improvement in yield and selectivity was also noted for other palladium catalysts supported on Al2O3+ ZrO2 and Al2O3+ Fe2O3, which gave 78% and 81% of monoarylated products when KOH was used as a base. Moreover, selectivity to 3 exceeded 80%
Table
Table 3. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd supported on alumina-based oxides in DMF.
Table 3. Results of the Heck coupling of iodobenzene with cyclohexene catalyzed by Pd supported on alumina-based oxides in DMF.
CatalystBasePhI conversion (%)Yield
1+2+3
(%)		Selectivity 1:2:3 Yield
4+5+6+7+8
(%)		Biphenyl
(%)
Pd/Al2O3 + ZrO2NaHCO3664117:3:80914
KOH897813:3:8447
Pd/Al2O3 + CeO2NaHCO3644214:10:761012
KOH906714:4:821815
Pd/Al2O3 + Fe2O3NaHCO3634715:6:7978
KOH988111:1:88125
Pd/Al2O3 NaHCO3583716:8:76714
NaOAc574316:7:7778
K2CO3864815:12:73929
NaOH905317:4:792215
KOH886512:0:881211
Reaction conditions: 2.68 × 10-3 mol of PhI, 8.77 × 10-3 mol of cyclohexene, 0.53% mol Pd, 2.5 × 10-3 mol of NaHCO3, 5 cm3 of DMF, 140 ºC, 4 h.

3. Experimental

3.1. Preparation of alumina-based supports

Alumina-based oxides were prepared by the sol-gel technique [41,42]. The proportion of ZrO2, Fe2O3 and CeO2 to Al2O3 was equal 10:100, 10:100 and 2:100. Specific surface area estimated according to BET method was ca. 200 m2/g.

3.2. Preparation of supported Pd(II) catalysts

First, the support (0.8 g) was impregnated, with stirring, in an aqueous acidic solution (8 cm3, CHCl = 0.09 mol/dm3) of PdCl2, containing 40 mg of Pd. After 72 h, the solution was decanted, and the Pd(II)-containing catalyst was washed three times with water and dried. The palladium content was estimated by the ICP method after mineralization of the weighted sample with aqua regia.The amount of palladium was from 1.3 to 1.9 wt % in the final catalysts.

3.3. Heck reaction procedure

The Heck reactions of iodobenzene with cyclohexene were carried out in a 50 cm3 Schlenk tube with magnetic stirring. The reagents: the catalyst, PdCl2(PhCN)2 (2.5 × 10-6–2.09 × 10-5 mol) or Pd(OAc)2 (8.46 × 10-7–2.01 × 10-5 mol) or Pd supported on alumina-based oxide (7.0 × 10-6, 9.4 × 10-6 or 1.41 × 10-5 mol), PhI (0.3 cm3, 2.68 × 10−3 mol), cyclohexene (0.5 cm3, 8.77 × 10−3 mol), base (NaHCO3, NaOAc, K2CO3, KOH, NaOH, 2.5x10-3 mol), and the solvent, [Bu4N]Br (0.75 g, 2.3 × 10−3 mol) or DMF (5 cm3), were introduced to the Schlenk tube under an N2 atmosphere. The tube was closed, and the reaction was carried out at 140 ºC for 4 h. Afterwards, organic products were separated by extraction with diethyl ether (twice with 10 cm3) and analyzed by GC–MS (Hewlett Packard 8452A) with dodecane (0.1 cm3, 4.4x10-4 mol) as internal standard. For reactions performed in DMF, diethyl ether (15 cm3) was added, and a sample was quenched with water (10 cm3). Organic products were extracted from the water phase with diethyl ether (15 cm3), and a combined ether solution was analyzed by GC. Products 1, 2, and 3 were identified by comparison of their MS spectra with literature data [49]. Five isomers of diarylated cyclohexenes were found in the GC, and their composition was confirmed by MS (m/z = 234, M+).

4. Conclusions

The Heck coupling of iodobenzene with cyclohexene performed with Pd(OAc)2 and PdCl2(PhCN)2 as catalyst precursors in molten [Bu4N]Br salt resulted in a maximum yield of monoarylated products amounting to ca. 60%. The soluble palladium species, [Bu4N]2[PdX4] complexes, and Pd(0) nanoparticles stabilized by tetrabutylammonium salt were most probably responsible for the observed reactivity. The same precursors used in DMF presented a very low catalytic activity. In contrast, palladium catalysts containing Pd(II) supported on Al2O3 and alumina-based mixed oxides, Al2O3-ZrO2, Al2O3-CeO2, Al2O3-Fe2O3, were quite effective in DMF, producing up to 46% of monoarylated products, with 4-phenylcyclohexene (3) being the predominant one. The same catalysts used in [Bu4N]Br presented a lower selectivity and produced 3-phenylcyclohexene (2) and 4-phenyl-cyclohexene (3) in comparable amounts, with a slight excess of 2. Different results obtained in with homogeneous and heterogeneous precursors can be explained by the contribution in the reaction course of insoluble, supported palladium species besides of soluble ones. The most attractive and promising results, up to 81% of monoarylated products, were obtained with heterogenized palladium catalysts in DMF, with KOH as the base. Excellent selectivity to 3 was also noted under such conditions.

Acknowledgements

Financial support of the Polish Ministry of Science and Higher Education (N164/COST/2008) and COST D40 are gratefully acknowledged. The authors are grateful to Hanna Grabowska and Mirosław Zawadzki (Polish Academy of Sciences, Wrocław) for preparation of alumina-based oxides, to Ms Agnieszka Boroń for testing of homogeneous catalysts, to Mr Marek Hojniak (Faculty of Chemistry, University of Wrocław) for GC and GC-MS analyses and to Mr Tomasz Borkowski and dr Wojciech Gil (Faculty of Chemistry, University of Wrocław) for XRD and TEM analyses.
  • Sample Availability: Samples of the compounds are available from the authors.

References and Notes

  1. Heck, R.F. Palladium-catalyzed reactions of organic halides with olefins. Acc. Chem. Res. 1979, 12, 146–151. [Google Scholar] [CrossRef]
  2. Beletskaya, I.P.; Cherpakov, A.V. The Heck Reaction as a Sharpening Stone of Palladium Catalysis. Chem. Rev. 2000, 100, 3009–3066. [Google Scholar] [CrossRef]
  3. Whitcombe, N.J.; Hii, K.K.; Gibson, S.E. Advances in the Heck chemistry of aryl bromides and chlorides. Tetrahedron 2001, 57, 7449–7476. [Google Scholar] [CrossRef]
  4. Trzeciak, AM.; Ziółkowski, J.J. Structural and mechanistic studies of Pd-catalyzed C-C bond formation: The case of carbonylation and Heck reaction. Coord. Chem. Rev. 2005, 249, 2308–2322. [Google Scholar] [CrossRef]
  5. Tsuji, I. Palladium Reagents and Catalysts. In New Perspectives for the 21 st Century; John Wiley & Sons, Ltd.: Chichester, West Sussex, UK, 2004; pp. 105–176. [Google Scholar]
  6. Bedford, R.B.; Cazin, C.S.J.; Holder, D. The development of palladium catalysts for C-C and C-heteroatom bond forming reactions of aryl chloride substrates. Coord. Chem. Rev. 2004, 248, 2283–2321. [Google Scholar] [CrossRef]
  7. Peris, E.; Crabtree, R.H. Recent homogeneous catalytic applications of chelate and pincer N-heterocyclic carbenes. Coord. Chem. Rev. 2004, 248, 2239–2246. [Google Scholar] [CrossRef]
  8. Gniewek, A.; Trzeciak, A.M.; Ziółkowski, J.J.; Kępiński, L.; Wrzyszcz, J.; Tylus, W. Pd-PVP colloid as catalyst for Heck and carbonylation reactions: TEM and XPS studies. J. Catal. 2005, 229, 332–343. [Google Scholar] [CrossRef]
  9. Reetz, M.T.; Westermann, E. Phosphane-Free Palladium-Catalyzed Coupling Reactions: The Decisive Role of Pd Nanoparticles. Angew. Chem. Int. Ed. 2000, 39, 165–168. [Google Scholar] [CrossRef]
  10. Calo, V.; Nacci, A.; Monopoli, A.; Laera, S.; Cioffi, N. Pd Nanoparticles Catalyzed Stereospecific Synthesis of β-Aryl Cinnamic Esters in Ionic Liquids. J. Org. Chem. 2003, 68, 2929–2933. [Google Scholar] [CrossRef]
  11. Pryjomska-Ray, I.; Trzeciak, A.M.; Ziółkowski, J.J. Base free efficient palladium catalysts of Heck reaction in molten tetrabutylammonium bromide. J. Mol. Catal. A: Chem. 2006, 257, 3–8. [Google Scholar]
  12. Glorius, F. N-heterocyclic carbenes in transition metal catalysis. In Top. Organomet. Chem.; Glorius, F., Ed.; Springer-Verlag: Berlin, Heidelberg, New York, NY, USA, 2007; Volume 3, pp. 1–218. [Google Scholar]
  13. Scott, M.N.; Nolan, S.P. Cross-coupling reactions catalyzed by palladium N-heterocyclic carbene complexes. In N-heterocyclic Carbenes in Synthesis; Nolan, S.P., Ed.; Wiley-VCH: Weinheim, Germany, 2006; pp. 55–70. [Google Scholar]
  14. Moreno-Manas, M.; Pleixats, R. Formation of carbon-carbon bonds under catalysis by transition-metal nanoparticles. Acc. Chem. Res. 2003, 36, 638–643. [Google Scholar] [CrossRef]
  15. Trzeciak, A.M.; Ziółkowski, J.J. Monomolecular, nanosized and heterogenized palladium catalysts for the Heck reaction. Coord. Chem. Rev. 2007, 251, 1281–1293. [Google Scholar]
  16. Evangelisti, C.; Panziera, N.; Petrici, P.; Vitulli, G.; Salvadori, P.; Battocchio, C.; Polzonetti, G. Palladium nanoparticles supported on polyvinylpyridine: Catalytic activity in Heck-type reactions and XPS structural studies. J. Catal. 2009, 262, 287–293. [Google Scholar]
  17. Calo, V.; Nacci, A.; Lopez, L.; Napoli, A. Arylation of α-substituted acrylates in ionic liquids catalyzed by a Pd-benzothiazole carbene complex. Tetrahedron Lett. 2001, 42, 4701–4703. [Google Scholar] [CrossRef]
  18. Calo, V.; Nacci, A.; Lopez, L.; Mannarini, N. Heck reaction in ionic liquids catalyzed by a Pd-benzothiazole carbene complex. Tetrahedron Lett. 2000, 41, 8973–8976. [Google Scholar] [CrossRef]
  19. Jeffery, T.; Galland, J.-C. Tetraalkylammonium salts in Heck-type reactions using an alkali-metal hydrogen carbonate or an alkali-metal acetate as the base. Tetrahedron Lett. 1994, 35, 4101–4106. [Google Scholar]
  20. Jeffery, T.; David, M. [Pd/Base/QX] catalyst systems for directing Heck-type reactions. Tetrahedron Lett. 1998, 39, 5751–5754. [Google Scholar] [CrossRef]
  21. Biffis, A.; Zecca, M.; Basato, M. Metallic palladium in the Heck reaction: active catalyst or convenient precursor? Eur. J. Chem. 2001, 5, 1131–1133. [Google Scholar]
  22. Pryjomska-Ray, I.; Gniewek, A.; Trzeciak, A.M.; Ziółkowski, J.J.; Tylus, W. Homogeneous/heterogenous palladium based catalytic system for Heck reaction. The reversible transfer of palladium between solution and support. Topics Catal. 2006, 40, 173–184. [Google Scholar]
  23. Pröckl, S.S.; Kleist, W.; Gruber, M.A.; Köhler, K. In situ generation of highly active dissolved palladium species from solid catalysts - a concept for the activation of aryl chlorides in the Heck reaction. Angew. Chem. Int. Ed. 2004, 43, 1881–1882. [Google Scholar] [CrossRef]
  24. Kleist, W.; Lee, J.-K.; Köhler, K. Pd/MOx materials synthesized by sol-gel coprecipitation as catalysts for carbon-carbon coupling reactions of aryl bromides and chlorides. Eur. J. Inorg. Chem. 2009, 2, 261–266. [Google Scholar]
  25. Köhler, K.; Wagner, M.; Djakovitch, L. Supported palladium as catalyst for carbon-carbon bond construction (Heck reaction) in organic synthesis. Catal. Today 2001, 66, 105–114. [Google Scholar]
  26. Pröckl, S.S.; Kleist, W.; Köhler, K. Design of highly active heterogeneous palladium catalysts for the activation of aryl chlorides in Heck reactions. Tetrahedron 2005, 61, 9855–9859. [Google Scholar] [CrossRef]
  27. Polshettiwar, V.; Len, C.; Fihri, A. Silica-supported palladium: sustainable catalysts for cross-coupling reactions. Coord. Chem. Rev. 2009, 253, 2599–2626. [Google Scholar] [CrossRef]
  28. Polshettiwar, V.; Molnar, A. Silica-supported Pd catalysts for Heck coupling reactions. Tetrahedron 2007, 63, 6949–6976. [Google Scholar] [CrossRef]
  29. Djakovitch, L.; Heise, H.; Köhler, K. Heck reactions between aryl halides and olefins catalysed by Pd-complexes entrapped into zeolites NaY. J. Organomet. Chem. 1999, 584, 16–26. [Google Scholar]
  30. Dams, M.; Drijkoningen, L.; Pauwels, B.; Van Tendeloo, G.; De Vos, D.E.; Jakobs, P.A. Pd-Zeolites as heterogeneous catalysts in Heck chemistry. J. Catal. 2002, 209, 225–236. [Google Scholar]
  31. Yin, Y.; Liebscher, J. Carbon-carbon coupling reactions catalyzed by heterogeneous palladium catalysts. Chem. Rev. 2007, 107, 133–173. [Google Scholar]
  32. Zhao, F.; Shirai, M.; Ikushima, Y.; Arai, M. The leaching and re-deposition of metal species from and onto conventional supported palladium catalysts in the Heck reaction of iodobenzene and methyl acrylate in N-methylpyrrolidone. J. Mol. Catal. A: Chem. 2002, 180, 211–219. [Google Scholar]
  33. Wagner, M.; Hartung, G.G.; Beller, M.; Köhler, K. Pd-catalyzed Heck arylation of cycloalkenes–studies on selectivity comparing homogeneous and heterogeneous catalysts. J. Mol. Catal. A: Chem. 2004, 219, 121–130. [Google Scholar]
  34. Hartung, G.; Koehler, K.; Beller, M. Highly selective palladium – catalyzed Heck reaction of aryl bromides with cycloalkenes. Org. Lett. 1999, 1, 709–711. [Google Scholar] [CrossRef]
  35. Kaganovsky, L.; Cho, K.-B.; Gelman, D. New trans-chelating ligands and their complexes and catalytic properties in the Mizoroki – Heck arylation of cyclohexene. Organometallics 2008, 27, 5139–5145. [Google Scholar] [CrossRef]
  36. Dodd, D.W.; Toews, H.E.; Carneiro, F.D.S.; Jennings, M.C.; Jones, N.D. Model intermolecular, asymmetric Heck reactions catalyzed by chiral pyridyloxazoline palladium(II) complexes. Inorg. Chim. Acta 2006, 329, 2850–2858. [Google Scholar]
  37. Berthiol, F.; Doucet, H.; Santelli, M. Heck reaction of aryl halides with linear or cyclic alkenes catalysed by tetraphosphine/palladium catalyst. Tetrahedron Lett. 2003, 44, 1221–1225. [Google Scholar] [CrossRef]
  38. Rosol, M.; Moyano, A. 1,-carbopalladated-4-ferrocenyl-1,3-oxazolines as catalysts for Heck reactions: Further evidence in support of the Pd(0)/Pd(II) mechanism. J. Organomet. Chem. 2005, 690, 2291–2296. [Google Scholar] [CrossRef]
  39. Wheatley, B.M.M.; Keay, B.A. Use of deuterium labelling studies to determine the stereochemical outcome of palladium migration during an asymmetric intermolecular Heck reaction. J. Org. Chem. 2007, 72, 7253–7259. [Google Scholar] [CrossRef]
  40. Gron, L.U.; Tinsley, A.S. Tailoring aqueous solvents for organic reactions: Heck coupling reactions in high temperature water. Tetrahedron Lett. 1999, 40, 227–230. [Google Scholar] [CrossRef]
  41. Gniewek, A.; Ziółkowski, J.J.; Trzeciak, A.M.; Zawadzki, M.; Grabowska, H.; Wrzyszcz, J. Palladium nanoparticles supported on alumina-based oxides as heterogeneous catalysts of the Suzuki-Miyaura reaction. J. Catal. 2008, 254, 121–130. [Google Scholar]
  42. Mieczyńska, E.; Pryjomska-Ray, I.; Trzeciak, A.M.; Grabowska, H.; Zawadzki, M. The Heck arylation of mono- and disubstituted olefins catalyzed by palladium supported on alumina-based oxides. New J. Chem. 2010, submitted. [Google Scholar]
  43. Wojtków, W.; Trzeciak, A.M.; Choukroun, R.; Pellegatta, J.L. Pd-colloid catalyzed methoxycarbonylation of iodobenzene in ionic liquids. J. Mol. Catal. A: Chem. 2004, 224, 81–86. [Google Scholar]
  44. De Vries, J.G. A unifying mechanism for all high-temperature Heck reactions. The role of palladium colloids and anionic species. Dalton Trans. 2006, 421–429. [Google Scholar] [CrossRef]
  45. Calo, V.; Nacci, A.; Monopoli, A.; Fornaro, A.; Sabbatini, L.; Cioffi, N.; Ditaranto, N. Heck reaction catalyzed by nanosized palladium on chitosan in ionic liquids. Organometallics 2004, 23, 5154–5158. [Google Scholar] [CrossRef]
  46. Colussi, S.; Trovarelli, A.; Groppi, G.; Llorca, J. The effect of CeO2 on the dynamics of Pd-PdO transformation over Pd/Al2O3 combustion catalysts. Catal. Comm. 2007, 8, 1263–1266. [Google Scholar] [CrossRef]
  47. Romanova, R.G.; Petrova, E.V. Acid-base surface propertis of binary systems based on aluminum and zirconium oxides. Kinet. Catal. 2006, 47, 138–147. [Google Scholar] [CrossRef]
  48. Enache, D.; Roy-Auberger, M.; Esterle, K.; Revel, R. Preparation of Al2O3-ZrO2 mixed supports; thair characteristics and hydrothermal stability. Colloids Surf. A: Physicochem. Eng. Aspects 2003, 220, 223–233. [Google Scholar]
  49. McLafferty, F.W.; Staffer, D.B. The Wiley/NBS Registry of Mass Spectra Data; Wiley-Interscience Publication, John Wiley&Sons: New York, NY, USA, 1989; p. 453. [Google Scholar]

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MDPI and ACS Style

Mieczyńska, E.; Trzeciak, A.M. Selective Heck Arylation of Cyclohexene with Homogeneous and Heterogeneous Palladium Catalysts. Molecules 2010, 15, 2166-2177. https://doi.org/10.3390/molecules15042166

AMA Style

Mieczyńska E, Trzeciak AM. Selective Heck Arylation of Cyclohexene with Homogeneous and Heterogeneous Palladium Catalysts. Molecules. 2010; 15(4):2166-2177. https://doi.org/10.3390/molecules15042166

Chicago/Turabian Style

Mieczyńska, Ewa, and Anna M. Trzeciak. 2010. "Selective Heck Arylation of Cyclohexene with Homogeneous and Heterogeneous Palladium Catalysts" Molecules 15, no. 4: 2166-2177. https://doi.org/10.3390/molecules15042166

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