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Molecules 2010, 15(3), 1161-1167;

A New Geldanamycin Analogue from Streptomyces hygroscopicus

School of Resources and Environment, Jilin Agricultural University, Changchun, 130118, China
Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, China
College of Plant Science, Jilin University, Changchun, 130062, China
Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China
Authors to whom correspondence should be addressed.
Received: 5 January 2010 / Revised: 10 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
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A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
Keywords: Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, H.; Sun, G.-Z.; Li, X.; Pan, H.-Y.; Zhang, Y.-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules 2010, 15, 1161-1167.

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