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Open AccessArticle

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

College of Chemical Engineering and Material, Heilongjiang University, Haerbin 150080, China
Mudanjiang Normal University, Mudanjiang 157012, China
Author to whom correspondence should be addressed.
Molecules 2010, 15(3), 1154-1160;
Received: 23 January 2010 / Revised: 25 February 2010 / Accepted: 2 March 2010 / Published: 2 March 2010
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields. View Full-Text
Keywords: copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides
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MDPI and ACS Style

Wang, C.; Liu, L.; Wang, W.; Ma, D.-S.; Zhang, H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules 2010, 15, 1154-1160.

AMA Style

Wang C, Liu L, Wang W, Ma D-S, Zhang H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules. 2010; 15(3):1154-1160.

Chicago/Turabian Style

Wang, Chaoyu; Liu, Lijuan; Wang, Wei; Ma, Dong-Sheng; Zhang, Hua. 2010. "Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand" Molecules 15, no. 3: 1154-1160.

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