Next Article in Journal
Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment
Previous Article in Journal
Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue
Open AccessArticle

Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs

1
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu 30013, Taiwan
2
Department of Obstetrics & Gynecology, Chang Bing Show Chwan Memorial Hospital, Lukang Zhen, Changhua County, Taiwan
3
Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan
4
Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu, 300, Taiwan
*
Authors to whom correspondence should be addressed.
Molecules 2010, 15(12), 8796-8803; https://doi.org/10.3390/molecules15128796
Received: 4 November 2010 / Revised: 29 November 2010 / Accepted: 1 December 2010 / Published: 2 December 2010
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10 to 100 μM. Methyl fenbufen amide had significant cytotoxic effects at a concentration of 100 μM. As the length of the alkyl amide side chain increased, the cytotoxic effects increased, and the octyl fenbufen amide had the greatest cytotoxic effect. After treatment with 30 μM octyl fenbufen amide, nearly seventy percent of the cells lost their viability. At the concentration of 10 μM, fenbufen amide analogs did not show cytotoxicity according to the MTT assay results. The NO scavenging activities of the fenbufen amide analogs were not significantly different from those of fenbufen. View Full-Text
Keywords: macrophage RAW 264.7; nitric oxide; anti-inflammatory; fenbufen amide analog macrophage RAW 264.7; nitric oxide; anti-inflammatory; fenbufen amide analog
Show Figures

Figure 1

MDPI and ACS Style

Lin, K.-I.; Yang, C.-H.; Huang, C.-W.; Jian, J.-Y.; Huang, Y.-C.; Yu, C.-S. Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs. Molecules 2010, 15, 8796-8803.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop