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Prooxidant/Antioxidant Ratio (ProAntidex) as a Better Index of Net Free Radical Scavenging Potential

Department of Physiology, Faculty of Medicine, 50603, University of Malaya, Kuala Lumpur, Malaysia
School of Medicine and Health Sciences, Monash University Sunway Campus, 46150, Petaling Jaya, Malaysia
Author to whom correspondence should be addressed.
Molecules 2010, 15(11), 7884-7892;
Received: 6 September 2010 / Revised: 1 October 2010 / Accepted: 19 October 2010 / Published: 3 November 2010
(This article belongs to the Special Issue Phenolics and Polyphenolics)
The antioxidant activity of several Malaysian plant extracts was analyzed simultaneously with their pro-oxidant capacity. This ratio represents an index (ProAntidex) of the net free radical scavenging ability of whole plant extracts. We observed that ethanolic extracts of Nephelium lappaceum peel, Fragaria x ananassa leaf, Lawsonia inermis leaf, Syzygium aqueum leaf and grape seed had a lower Pro-Antidex than the commercially available Emblica™ extract which is an antioxidant agent with very low pro-oxidant activity. Among the aqueous extracts, Lawsonia inermis leaf, Nephelium mutobile leaf and grape seed had lower pro-oxidant activity compared to the Emblica™ extract. Among these extracts, aqueous extract of Nephelium mutobile leaf had a very low index of 0.05 compared to 0.69 for Emblica™. Most of the extracts had a far lower ProAntidex compared to the Vitamin C. The index enables us to identify extracts with high net free radical scavenging activity potential. The ProAntidex is beneficial as a screening parameter to the food industries and healthcare. View Full-Text
Keywords: pro-oxidant; DPPH; reducing power; antioxidants; EmblicaTM pro-oxidant; DPPH; reducing power; antioxidants; EmblicaTM
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MDPI and ACS Style

Ling, L.T.; Palanisamy, U.D.; Cheng, H.M. Prooxidant/Antioxidant Ratio (ProAntidex) as a Better Index of Net Free Radical Scavenging Potential. Molecules 2010, 15, 7884-7892.

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