Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats
Abstract
:Introduction
Results and Discussion
Substance or class | Concentration ± SD (mg·g-1) |
---|---|
Gallic acid derivatives | |
Gallic acid | 103.08 ± 0.64 |
Methyl gallate | 228.04 ± 1.11 |
Unknown gallic acid derivatives | 329.59 ± 3.65 |
Total | 728.71 ± 3.78 |
Catechins | |
(+)-Catechin | 21.14 ± 0.45 |
Unknown catechins | 4.34 ± 0.08 |
Total | 29.70 ± 0.46 |
Flavonoids | |
Amenthoflavone | 29.33 ± 0.82 |
Unknown flavonoids | 92.76 ± 0.75 |
Total | 122.09 ± 1.07 |
Models | Groups | Ulcer index | Inhibition |
---|---|---|---|
(n = 7) | (mean ± SD) | (%) | |
Ethanol | Vehicle | 34.4 ± 14.2 | - |
50 mg·kg-1 AcF | 11.6 ± 6.6a | 66.2 | |
100 mg·kg-1 AcF | 22.8 ± 12.6 | 33.7 | |
200 mg·kg-1 AcF | 31.4 ± 10.5 | 8.7 | |
30 mg·kg-1 lansoprazole | 1.5 ± 0.8a | 95.6 |
Experimental
Plant material, extraction and isolation
Animals
Drugs
Ethanol-induced gastric lesion in rats
Determination of prostaglandin PGE2 synthesis
Determination of mucus in gastric content
Ethanol-induced gastric lesion in NEM and L-NAME- pretreatment rats
Histology of ethanol-induced gastric lesions
Statistical analysis
Conclusions
Acknowledgements
References
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Luiz-Ferreira, A.; Almeida, A.C.A.d.; Cola, M.; Barbastefano, V.; Almeida, A.B.A.d.; Batista, L.M.; Farias-Silva, E.; Pellizzon, C.H.; Hiruma-Lima, C.A.; Santos, L.C.; et al. Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Molecules 2010, 15, 7153-7166. https://doi.org/10.3390/molecules15107153
Luiz-Ferreira A, Almeida ACAd, Cola M, Barbastefano V, Almeida ABAd, Batista LM, Farias-Silva E, Pellizzon CH, Hiruma-Lima CA, Santos LC, et al. Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Molecules. 2010; 15(10):7153-7166. https://doi.org/10.3390/molecules15107153
Chicago/Turabian StyleLuiz-Ferreira, Anderson, Ana Cristina Alves de Almeida, Maíra Cola, Victor Barbastefano, Ana Beatriz Albino de Almeida, Leônia Maria Batista, Elisângela Farias-Silva, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Lourdes Campaner Santos, and et al. 2010. "Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats" Molecules 15, no. 10: 7153-7166. https://doi.org/10.3390/molecules15107153
APA StyleLuiz-Ferreira, A., Almeida, A. C. A. d., Cola, M., Barbastefano, V., Almeida, A. B. A. d., Batista, L. M., Farias-Silva, E., Pellizzon, C. H., Hiruma-Lima, C. A., Santos, L. C., Vilegas, W., & Brito, A. R. M. S. (2010). Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Molecules, 15(10), 7153-7166. https://doi.org/10.3390/molecules15107153