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Molecules 2010, 15(1), 83-92;

Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, No.158-139, Zhongshan Road, Dalian 116012, China
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Author to whom correspondence should be addressed.
Received: 30 November 2009 / Revised: 17 December 2009 / Accepted: 23 December 2009 / Published: 28 December 2009
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A highly efficient transition-metal-free catalytic system Br2/NaNO2/H2O has been developed for a robust and economic acid-free aerobic oxidation of sulfides. It is noteworthy that the sulfide function reacts under mild conditions without over-oxidation to sulfone. The role of NaNO2as an efficient NO equivalent for the activation of molecular oxygen was identified. Under the optimal conditions, a broad range of sulfide substrates were converted into their corresponding sulfoxides in high yields by molecular oxygen. The present catalytic system utilizes cheap and readily available agents as the catalysts, exhibits high selectivity for sulfoxide products and releases only innocuous water as the by-products. View Full-Text
Keywords: aerobic oxidation; sulfids; Br2; NaNO2; molecular oxygen aerobic oxidation; sulfids; Br2; NaNO2; molecular oxygen

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, H.; Chen, C.; Liu, R.; Xu, Q.; Zhao, W. Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions. Molecules 2010, 15, 83-92.

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