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Molecules 2009, 14(6), 2212-2225;

Examination of Imprinting Process with Molsidomine as a Template

Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 7 May 2009 / Revised: 4 June 2009 / Accepted: 11 June 2009 / Published: 17 June 2009
(This article belongs to the Special Issue ECSOC-12)
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Eight different functional monomers were used with ethylene glycol dimethacrylate as a cross-linker and molsidomine as a template to obtain molecularly imprinted polymers (MIPs). Non-covalent interactions between molsidomine and each functional monomer in DMSO prior to thermal bulk polymerization were utilized. On the basis of calculated imprinting factors, MIP prepared with N,N’-diallyltartaramide was chosen for further investigations. Examination of interactions in the prepolymerization complex between molsidomine and N,N’-diallyltartaramide was performed using the Job method. The absorbance of isomolar solutions reaching a maximum for the molar ratio of template to monomer equal to 1:4. Scatchard analysis was used for estimation of the dissociation constants and the maximum amounts of binding sites. The polymer based on N,N’-diallyltartaramide has two classes of heterogeneous binding sites characterized by two values of Kd and two Bmax: Kd(1) = 1.17 mM-1 and Bmax(1) = 0.8 μmol/mg for the higher affinity binding sites, and Kd(2) = 200 μM-1 and Bmax(2) = 2.05 μmol/mg for the lower affinity binding sites. Furthermore, effects of pH and organic solvent on binding properties of MIP and NIP were investigated, together with release of molsidomine from both MIP and NIP. View Full-Text
Keywords: molsidomine; molecularly imprinted polymers; sustained release molsidomine; molecularly imprinted polymers; sustained release

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Luliński, P.; Maciejewska, D. Examination of Imprinting Process with Molsidomine as a Template. Molecules 2009, 14, 2212-2225.

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