Next Article in Journal
Discovery of Artemisinin (Qinghaosu)
Previous Article in Journal
Synthesis and Biological Evaluation of Novel 1-Alkyltryptophan Analogs as Potential Antitumor Agents
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(12), 5349-5361;

Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui)

School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine 510405, Guangzhou, China
Author to whom correspondence should be addressed.
Received: 30 October 2009 / Revised: 4 December 2009 / Accepted: 14 December 2009 / Published: 21 December 2009
Full-Text   |   PDF [488 KB, uploaded 18 June 2014]   |  


Radix Angelicae Sinensisis (RAS) is one of the most popular traditional Chinese herbal medicines. In the present study, six RAS extracts (i.e., phenolic extract PE, petroleum ether extract PEE, ethyl acetate extract EAE, absolute ethanol extract AEE, 95% ethanol extract 95 EE, and water extract WE) were prepared and their antioxidant activities measured by DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS [2,2′-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid diammonium salt)], Reducing power, •O2– and lipid peroxidation assays. In general, PE, PEE and EAE had relatively high antioxidant activity, followed by AEE with moderate activity, as compared with 95 EE and WE that had low activity. Their phenolic contents (including total phenolic, ferulic acid, caffeic acid, same as below) were then determined by HPLC or spectrophotometry. The sequence of phenolic contents was roughly identical with that of antioxidant activity. When the values of 1/IC50 of various antioxidant assays were used to evaluate the level of antioxidant of the RAS extracts, (plot between 1/IC50 values and phenolic contents), the correlation coefficient (R) ranged from 0.642 to 0.941, with an average value of 0.839. Significant positive correlations demonstrated that the antioxidant effects of RAS might generally be considered a result of the presence of the phenolic compounds, especially ferulic acid and caffeic acid. View Full-Text
Keywords: Radix Angelicae Sinensis; antioxidant; phenolic; correlation Radix Angelicae Sinensis; antioxidant; phenolic; correlation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Li, X.; Wu, X.; Huang, L. Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui). Molecules 2009, 14, 5349-5361.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top