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Open AccessArticle

Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker

Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens 15773, Greece
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Molecules 2009, 14(10), 3914-3921; https://doi.org/10.3390/molecules14103914
Received: 8 September 2009 / Revised: 29 September 2009 / Accepted: 30 September 2009 / Published: 30 September 2009
(This article belongs to the Special Issue Solid Phase Synthesis)
An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product. View Full-Text
Keywords: 2-aminofuranones; solid-phase synthesis; heterocycles; lactones; acylations 2-aminofuranones; solid-phase synthesis; heterocycles; lactones; acylations
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MDPI and ACS Style

Matiadis, D.; Prousis, K.C.; Igglessi-Markopoulou, O. Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker. Molecules 2009, 14, 3914-3921. https://doi.org/10.3390/molecules14103914

AMA Style

Matiadis D, Prousis KC, Igglessi-Markopoulou O. Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker. Molecules. 2009; 14(10):3914-3921. https://doi.org/10.3390/molecules14103914

Chicago/Turabian Style

Matiadis, Dimitris; Prousis, Kyriakos C.; Igglessi-Markopoulou, Olga. 2009. "Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker" Molecules 14, no. 10: 3914-3921. https://doi.org/10.3390/molecules14103914

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