Next Article in Journal
Polyphenol Content and Antioxidant Activity of Fourteen Wild Edible Fruits from Burkina Faso
Previous Article in Journal
Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles
Article Menu

Export Article

Open AccessArticle
Molecules 2008, 13(3), 567-580;

Antimicrobial Activity of Some New Thioureides Derived from 2-(4-Chlorophenoxymethyl)benzoic Acid

Pharmaceutical Chemistry Department, Faculty of Farmacy, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, sect. 2, 020956, Bucharest, Romania
Microbiology-Immunology Department, Faculty of Biology, University of Bucharest, Ale. Portocalelor 1-3, sect. 5, Bucharest, Romania
Institute of Virology “Prof. St. Nicolau”, Sos. M. Bravu, 36, sect.2, Bucharest, Romania
Author to whom correspondence should be addressed.
Received: 29 January 2008 / Revised: 29 February 2008 / Accepted: 29 February 2008 / Published: 4 March 2008
Full-Text   |   PDF [361 KB, uploaded 18 June 2014]   |  


We report here the characterisation of eight newly synthesized thioureides of 2-(4-chlorophenoxymethyl)-benzoic acid and the evaluation of the in vitro antimicrobialactivity of the new compounds against Gram-positive [Listeria monocytogenes,Staphylococcus aureus, Bacillus subtilis], Gram-negative [Psedomonas aeruginosa,Escherichia coli, Salmonella enteritidis], as well as Candida spp., using both reference andclinical multidrug resistant strains to establish the minimal inhibitory concentration (MIC)values. Our results showed that the tested compounds exhibited specific antimicrobialactivities, both concerning the spectrum of antimicrobial activity and the correspondingMIC values, which ranged widely between 1024 and 32 μg/mL, depending on the natureand position of the substituents on the benzene ring. The most active compounds were N-[2-(4-chlorophenoxymethyl)-benzoyl]-N'-(2,6-dichlorophenyl)-thiourea (5g) and N-[2-(4-chlorophenoxymethyl)-benzoyl]-N'-(4-bromophenyl)-thiourea (5h), which showed a broadspectrum of antimicrobial activity against enterobacterial strains (E. coli and S. enteritidis),P. aeruginosa, S. aureus and Candida spp. All the tested compounds except 5f were highly active against S. aureus (MIC=32 μg/mL), suggesting their possible use in the treatment ofMRSA infections. Four of compounds also exhibited antifungal activity (MIC =256-32μg/mL) against C. albicans, but L. monocytogenes as well as B. subtilis were resistant toall tested compounds. Our studies thus demonstrated that among other biological activities,the thioureides of 2-(4-chlorophenoxymethyl)-benzoic acid also exhibit selective andeffective antimicrobial properties that could lead to the selection and use of thesecompounds as efficient antimicrobial agents, especially for the treatment of multidrugresistant infections. View Full-Text
Keywords: Thioureides; 2-(4-chlorophenoxymethyl)-benzoic acid; antimicrobial activity Thioureides; 2-(4-chlorophenoxymethyl)-benzoic acid; antimicrobial activity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Limban, C.; Chifiriuc, M.-C.B.; Missir, A.-V.; Chiriţă, I.C.; Bleotu, C. Antimicrobial Activity of Some New Thioureides Derived from 2-(4-Chlorophenoxymethyl)benzoic Acid. Molecules 2008, 13, 567-580.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top