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Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB, Brazil
Laboratório de Produtos Naturais, Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP, Brazil
Author to whom correspondence should be addressed.
Molecules 2008, 13(12), 3198-3223;
Received: 30 July 2008 / Revised: 7 November 2008 / Accepted: 2 December 2008 / Published: 17 December 2008
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals. View Full-Text
Keywords: Alkaloids; Antiulcer activity; Peptic ulcer; Review Alkaloids; Antiulcer activity; Peptic ulcer; Review
MDPI and ACS Style

De Sousa Falcão, H.; Leite, J.A.; Barbosa-Filho, J.M.; De Athayde-Filho, P.F.; De Oliveira Chaves, M.C.; Moura, M.D.; Ferreira, A.L.; De Almeida, A.B.A.; Souza-Brito, A.R.M.; De Fátima Formiga Melo Diniz, M.; Batista, L.M. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules 2008, 13, 3198-3223.

AMA Style

De Sousa Falcão H, Leite JA, Barbosa-Filho JM, De Athayde-Filho PF, De Oliveira Chaves MC, Moura MD, Ferreira AL, De Almeida ABA, Souza-Brito ARM, De Fátima Formiga Melo Diniz M, Batista LM. Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review. Molecules. 2008; 13(12):3198-3223.

Chicago/Turabian Style

De Sousa Falcão, Heloina, Jacqueline Alves Leite, José Maria Barbosa-Filho, Petrônio Filgueiras De Athayde-Filho, Maria Célia De Oliveira Chaves, Marcelo Dantas Moura, Anderson Luiz Ferreira, Ana Beatriz Albino De Almeida, Alba Regina Monteiro Souza-Brito, Margareth De Fátima Formiga Melo Diniz, and Leônia Maria Batista. 2008. "Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review" Molecules 13, no. 12: 3198-3223.

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