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Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
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Molecules 2006, 11(6), 486-495; https://doi.org/10.3390/11060486
Received: 26 April 2006 / Revised: 23 May 2006 / Accepted: 29 May 2006 / Published: 23 June 2006
Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug. View Full-Text
Keywords: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase. CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase.
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MDPI and ACS Style

Walsh, A.J.; Davis, M.L.; Fraser, W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 2006, 11, 486-495. https://doi.org/10.3390/11060486

AMA Style

Walsh AJ, Davis ML, Fraser W. Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules. 2006; 11(6):486-495. https://doi.org/10.3390/11060486

Chicago/Turabian Style

Walsh, Andrew J., Michael L. Davis, and William Fraser. 2006. "Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate" Molecules 11, no. 6: 486-495. https://doi.org/10.3390/11060486

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