Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity
Abstract
:Introduction
Results and Discussion
Synthesis
Properties
IR Spectra
Compound | νC=N | νAr-OH | ν>C=O | ρr | ρw | νSO42- | |||
---|---|---|---|---|---|---|---|---|---|
ν1 | ν2 | ν3 | ν4 | ||||||
C18H17N3O2 | 1653 | 3210- 3370 1140 | 1615 | - | - | - | - | - | - |
[Cu(C18H16N3O2)(H2O)2]Cl (a) | 1640 | - 1120 | 1594 | 897 | 572 | - | - | - | - |
C30H28N6O2 | 1654 | - | 1595 | - | - | - | - | - | |
[Cu2(C30H28N6O2)(SO4)2] (b) | 1639 | - | 1565 | - | 995 | 462 | 1050 1105 1170 | 574 610 641 |
Electronic spectra.
Compound | Transitions d-d (cm-1) | Geometry | ||
---|---|---|---|---|
[Cu(C18H16N3O2)(H2O)2]Cl | x2-y2 → xz; yz; xy | C2v | ||
14600 | ||||
[Cu2(C30H28N6O2)(SO4)2] | - | xy→xz; yz 13570 | xy→z2; x2-y2 14830 | Td deformed |
ESR spectra
Antimicrobial activity assays
Conclusions
- a)
- the qualitative anti-microbial activity screening results of the tested compounds proved that the most efficient test method was the spot method.
- b)
- the quantitative anti-microbial activity test results proved that both the ligands and the complex combinations have specific anti-microbial activity, depending on the microbial species tested.
Experimental
General
Synthesis of the Schiff base 1-phenyl-2,3-dimethyl-4-(N-salicylidene)-3-pyrazolin-5-one (ASAAP)
Synthesis of the Schiff base bis(1-phenyl-2,3-dimethyl-3-pyrazolin-5-one-4-imino) terephthalic aldehyde (ATAAP)
Synthesis of the complex [Cu(C18H16N3O2)(H2O)2]Cl (a)
Synthesis of the complex [Cu2(C30H28N6O2)(SO4)2] (b)
Biological assays
Acknowledgements
References
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Rosu, T.; Pasculescu, S.; Lazar, V.; Chifiriuc, C.; Cernat, R. Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity. Molecules 2006, 11, 904-914. https://doi.org/10.3390/11110904
Rosu T, Pasculescu S, Lazar V, Chifiriuc C, Cernat R. Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity. Molecules. 2006; 11(11):904-914. https://doi.org/10.3390/11110904
Chicago/Turabian StyleRosu, Tudor, Simona Pasculescu, Veronica Lazar, Carmen Chifiriuc, and Raluca Cernat. 2006. "Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity" Molecules 11, no. 11: 904-914. https://doi.org/10.3390/11110904