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Molecules 2005, 10(10), 1351-1357;

A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China
Author to whom correspondence should be addressed.
Received: 6 July 2005 / Revised: 15 August 2005 / Accepted: 17 August 2005 / Published: 31 October 2005
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A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells. View Full-Text
Keywords: 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation. 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation.

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Ouyang, G.; Song, B.; Zhang, H.; Yang, S.; Jin, L.; Li, Q.; Hu, D. A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation. Molecules 2005, 10, 1351-1357.

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