Next Article in Journal
Late Developed Unusual Nasal Involvement of Postoperative Maxillary Cyst Following Maxillary Sinus Augmentation: A Case Report
Next Article in Special Issue
Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
Previous Article in Journal
Cultivation of Solanum lycopersicum under Glass Coated with Nanosized Upconversion Luminophore
Previous Article in Special Issue
Differential Scanning Calorimetry as a New Method to Evaluate the Effectiveness of Rejuvenating Agents in Bitumens
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 11
Issue 22
10.3390/app112210727
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease

by
Ezgi Saylam
1,2,
Yigit Akkaya
1,2,
Elif Ilhan
1,2,
Sumeyye Cesur
1,3,
Ece Guler
1,4,
Ali Sahin
5,
Muhammmet Emin Cam
1,4,6,
Nazmi Ekren
1,
Faik Nuzhet Oktar
1,2,
Oguzhan Gunduz
1,3,
Denisa Ficai
7 and
Anton Ficai
7,8,*
1
Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, İstanbul 34000, Turkey
2
Department of Bioengineering, Faculty of Engineering, Marmara University, İstanbul 34000, Turkey
3
Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, İstanbul 34000, Turkey
4
Department of Pharmacology, Faculty of Pharmacy, Marmara University, İstanbul 34000, Turkey
5
Department of Biochemistry, School of Medicine, Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul 34000, Turkey
6
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
7
Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania
8
Academy of Romanian Scientists, Ilfov St. 3, 060042 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(22), 10727; https://doi.org/10.3390/app112210727
Submission received: 18 October 2021 / Revised: 6 November 2021 / Accepted: 9 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Synthesis and Characterization of Nanoparticles Volume II: Organic Aspects)
Browse Figures
Versions Notes

Abstract

Parkinson’s disease, the second most common neurodegenerative disease in the world, develops due to decreased dopamine levels in the basal ganglia. Levodopa, a dopamine precursor used in the treatment of Parkinson’s disease, can be used as a drug delivery system. This study presents an approach to the use of 3D-printed levodopa-loaded neural tissue scaffolds produced with polylactic acid (PLA) and chitosan (CS) for the treatment of Parkinson’s disease. Surface morphology and pore sizes were examined by scanning electron microscopy (SEM). Average pore sizes of 100–200 µm were found to be ideal for tissue engineering scaffolds, allowing cell penetration but not drastically altering the mechanical properties. It was observed that the swelling and weight loss behaviors of the scaffolds increased after the addition of CS to the PLA. Levodopa was released from the 3D-printed scaffolds in a controlled manner for 14 days, according to a Fickian diffusion mechanism. Mesenchymal stem cells (hAD-MSCs) derived from human adipose tissue were used in MTT analysis, fluorescence microscopy and SEM studies and confirmed adequate biocompatibility. Overall, the obtained results show that PLA/CS 3D-printed scaffolds have an alternative use for the levodopa delivery system for Parkinson’s disease in neural tissue engineering applications.
Keywords: levodopa; Parkinson’s disease; 3D-printed scaffold; biomaterials; tissue engineering; drug delivery levodopa; Parkinson’s disease; 3D-printed scaffold; biomaterials; tissue engineering; drug delivery

Share and Cite

MDPI and ACS Style

Saylam, E.; Akkaya, Y.; Ilhan, E.; Cesur, S.; Guler, E.; Sahin, A.; Cam, M.E.; Ekren, N.; Oktar, F.N.; Gunduz, O.; et al. Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease. Appl. Sci. 2021, 11, 10727. https://doi.org/10.3390/app112210727

AMA Style

Saylam E, Akkaya Y, Ilhan E, Cesur S, Guler E, Sahin A, Cam ME, Ekren N, Oktar FN, Gunduz O, et al. Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease. Applied Sciences. 2021; 11(22):10727. https://doi.org/10.3390/app112210727

Chicago/Turabian Style

Saylam, Ezgi, Yigit Akkaya, Elif Ilhan, Sumeyye Cesur, Ece Guler, Ali Sahin, Muhammmet Emin Cam, Nazmi Ekren, Faik Nuzhet Oktar, Oguzhan Gunduz, and et al. 2021. "Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease" Applied Sciences 11, no. 22: 10727. https://doi.org/10.3390/app112210727

APA Style

Saylam, E., Akkaya, Y., Ilhan, E., Cesur, S., Guler, E., Sahin, A., Cam, M. E., Ekren, N., Oktar, F. N., Gunduz, O., Ficai, D., & Ficai, A. (2021). Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease. Applied Sciences, 11(22), 10727. https://doi.org/10.3390/app112210727

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop