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Entropy 2018, 20(4), 224; https://doi.org/10.3390/e20040224

Information Thermodynamics of the Cell Signal Transduction as a Szilard Engine

Clinical Research Center for Medical Equipment Development, Department of Pathology, Kyoto University Hospital, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto 606-8057, Japan
Received: 27 February 2018 / Revised: 20 March 2018 / Accepted: 22 March 2018 / Published: 26 March 2018
(This article belongs to the Section Information Theory, Probability and Statistics)
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Abstract

A cell signaling system is in a non-equilibrium state, and it includes multistep biochemical signaling cascades (BSCs), which involve phosphorylation of signaling molecules, such as mitogen-activated protein kinase (MAPK) pathways. In this study, the author considered signal transduction description using information thermodynamic theory. The ideal BSCs can be considered one type of the Szilard engine, and the presumed feedback controller, Maxwell’s demon, can extract the work during signal transduction. In this model, the mutual entropy and chemical potential of the signal molecules can be redefined by the extracted chemical work in a mechanicochemical model, Szilard engine, of BSC. In conclusion, signal transduction is computable using the information thermodynamic method. View Full-Text
Keywords: Szilard engine; mutual entropy; signal transduction; information thermodynamics; fluctuation theorem Szilard engine; mutual entropy; signal transduction; information thermodynamics; fluctuation theorem
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Tsuruyama, T. Information Thermodynamics of the Cell Signal Transduction as a Szilard Engine. Entropy 2018, 20, 224.

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