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Using Entropy Leads to a Better Understanding of Biological Systems

Department of Oncology, University of Alberta, 11560 University Ave. Edmonton, AB T6G 1Z2, Canada
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Entropy 2010, 12(12), 2450-2469; https://doi.org/10.3390/e12122450
Received: 4 November 2010 / Revised: 7 December 2010 / Accepted: 15 December 2010 / Published: 17 December 2010
(This article belongs to the Special Issue Emergence in Chemical Systems)
In studying biological systems, conventional approaches based on the laws of physics almost always require introducing appropriate approximations. We argue that a comprehensive approach that integrates the laws of physics and principles of inference provides a better conceptual framework than these approaches to reveal emergence in such systems. The crux of this comprehensive approach hinges on entropy. Entropy is not merely a physical quantity. It is also a reasoning tool to process information with the least bias. By reviewing three distinctive examples from protein folding dynamics to drug design, we demonstrate the developments and applications of this comprehensive approach in the area of biological systems. View Full-Text
Keywords: entropy; inference; folding dynamics; tubulin expression level; aptamer entropy; inference; folding dynamics; tubulin expression level; aptamer
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Tseng, C.-Y.; Tuszynski, J.A. Using Entropy Leads to a Better Understanding of Biological Systems. Entropy 2010, 12, 2450-2469.

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