Special Issue "Nucleic Acid Analogs"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 October 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Lajos Kovacs
Nucleic Acids Laboratory, Department of Medicinal Chemistry, Universtiy of Szeged, Dóm tér 8, H-6720 Szeged, Hungary
Website: http://www.mdche.u-szeged.hu/~kovacs/nal.html
E-Mail: kovacs.lajos@med.u-szeged.hu
Phone: +36 62 54 51 45
Fax: +36 62 42 59 71
Interests: preparative organic chemistry of carbohydrates; nucleobases; nucleosides; C-nucleosides; peptide nucleic acids; indoles; alkaloids; polyamines; heterocycles; protecting groups; chemical information management

Special Issue Information

Dear Colleagues,

The naissance and development of molecular biology has greatly benefited from the support of the chemistry of  important biomolecules (amino acids, peptides, proteins, carbohydrates, nucleic acids). This fact may sound trivial for chemists but it has not been widely acknowledged by the practitioners of modern biology. Consequently, chemistry has long been considered as an auxiliary science of biology. Indeed, the methods routinely used in contemporary biological research largely rely on developments from fields outside the scope of biology itself, mainly from chemical, physical and IT sciences. This is a fortunate synergy among fields seemingly far from each other.

Chemistry, however, is a science in its own right, with aims and scopes originating not only from other disciplines but from the curiosity of its pursuers. The role of nucleic acids has been firmly established since the deciphering of double helix structure of DNA and the above outlined tremendous development of molecular biology methods with huge impact on other fields as well. The contribution of nucleic acid chemistry to this success is not ceasing, just remember the everyday use of DNA sequencing methods. Along with this development, nucleic acid research is taking new directions as well: synthesis of even more complex molecules like RNA, synthetic analogues (peptide nucleic acids, locked nucleic acids, morpholino oligos, conjugates etc.), superior analytical methods (e.g. those based on mass spectrometry), study of higher-order structures (triple and quadruple helices), investigation of molecular electronic devices based on nucleic acid analogues, to name just a few. I would like to cordially invite everyone involved it his exciting field and to contribute to the success of our Special Issue "Nucleic Acid Analogs" by presenting her/his results.

Prof. Dr. Lajos Kovacs
Guest Editor

Keywords

adenine; adenosine; ADP; AMP; antigene; antisense; antiviral activity; aptamer; asthma; ATP; avidin; beacons; bioconjugation; biosensor; biotin; branched oligonucleotides; cAMP; capillary gel-electrophoresis; carbon-paste electrodes; cationic liposomes; CDP; cellular uptake; cleaving DNAzyme; click chemistry; CMP; colloidal gold nanoparticles; colorimetric detection; combinatorial chemistry; copper(i)-catalyzed azide-alkyne reaction; crossover molecules; CTP; cycloadditions; cytosine; cytidine; density oligonucleotide arrays; Diels-Alder bioconjugation; directed synthesis; disposable DNA; DNA microarrays; DNA synthesis; DNA triple-helix; DNA-directed immobilization; double-stranded DNA; double-stranded RNA; drug-delivery; electrochemical detection; electrochemical stripping detection; fluorescent oligonucleotides; GDP; gene delivery; GMP; gold electrode; gold surfaces; GTP; guanine; guanosine; HCMV; HIV; HSV; human telomerase; human-immunodeficiency-virus; hybridization; immo bilization; intracellular delivery ; in-vitro selection; light-up probes; LNA; locked nucleic-acids; magnet assisted transfection; magnetic gene transfection; magnetic nanoparticles ; mass-spectrometry; microarray; molecular recognition; morpholino analogues; nanoparticles; NF-kappa-b; nucleic-acid based technology; nucleobases; nucleosides; nucleotides; oligonucleotide dendrimers; oligonucleotide synthesis; on-column conjugation; peptide nucleic acid; phosphorothioate oligodeoxynucleotides; pH-sensitive liposomes; plasmid-DNA; PNA; PNA molecular beacons; quadruplex nucleic acids reversible polymers; RNA interference; RNA liposomes; RNA synthesis; self-assembled monolayers (SAM); self-assembly; sensor; short interfering RNA; shRNA; single-nucleotide polymorphisms; siRNA; site-specific modification; small interfering RNA; SNP; streptavidin; surface-plasmon resonance; switching signaling aptamers; synthesis; TDP; templated organic synthesis; thymine; thymidine; TMP; transcript ion factor; TTP; UDP; UMP; uracil; uridine; UTP; viral vectors; voltammetry; walled carbon nanotubes

Published Papers (17 papers)

by , , ,  and
Molecules 2013, 18(1), 225-235; doi:10.3390/molecules18010225
Received: 1 November 2012; in revised form: 14 December 2012 / Accepted: 21 December 2012 / Published: 27 December 2012
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by , , , , , , , , ,  and
Molecules 2012, 17(12), 13712-13726; doi:10.3390/molecules171213712
Received: 12 October 2012; in revised form: 10 November 2012 / Accepted: 13 November 2012 / Published: 22 November 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (901 KB) | HTML Full-text | XML Full-text | Supplementary Files
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by , , ,  and
Molecules 2012, 17(12), 13825-13843; doi:10.3390/molecules171213825
Received: 17 October 2012; in revised form: 16 November 2012 / Accepted: 16 November 2012 / Published: 22 November 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (285 KB) | HTML Full-text | XML Full-text

by , ,  and
Molecules 2012, 17(11), 13503-13529; doi:10.3390/molecules171113503
Received: 21 September 2012; in revised form: 7 November 2012 / Accepted: 9 November 2012 / Published: 14 November 2012
Show/Hide Abstract | Cited by 9 | PDF Full-text (346 KB)

by , , ,  and
Molecules 2012, 17(11), 13376-13389; doi:10.3390/molecules171113376
Received: 21 September 2012; in revised form: 30 October 2012 / Accepted: 1 November 2012 / Published: 9 November 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (520 KB)
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by  and
Molecules 2012, 17(11), 13073-13086; doi:10.3390/molecules171113073
Received: 24 September 2012; in revised form: 1 November 2012 / Accepted: 1 November 2012 / Published: 5 November 2012
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by , , ,  and
Molecules 2012, 17(11), 13087-13097; doi:10.3390/molecules171113087
Received: 29 September 2012; in revised form: 31 October 2012 / Accepted: 1 November 2012 / Published: 5 November 2012
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by ,  and
Molecules 2012, 17(11), 12665-12703; doi:10.3390/molecules171112665
Received: 21 September 2012; in revised form: 19 October 2012 / Accepted: 19 October 2012 / Published: 26 October 2012
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by  and
Molecules 2012, 17(10), 12378-12392; doi:10.3390/molecules171012378
Received: 19 September 2012; in revised form: 16 October 2012 / Accepted: 17 October 2012 / Published: 22 October 2012
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by , ,  and
Molecules 2012, 17(10), 12102-12120; doi:10.3390/molecules171012102
Received: 12 September 2012; in revised form: 12 October 2012 / Accepted: 12 October 2012 / Published: 16 October 2012
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by ,  and
Molecules 2012, 17(10), 12061-12071; doi:10.3390/molecules171012061
Received: 14 September 2012; in revised form: 3 October 2012 / Accepted: 10 October 2012 / Published: 15 October 2012
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by  and
Molecules 2012, 17(10), 11630-11654; doi:10.3390/molecules171011630
Received: 30 August 2012; in revised form: 25 September 2012 / Accepted: 26 September 2012 / Published: 28 September 2012
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by , , ,  and
Molecules 2012, 17(9), 11089-11102; doi:10.3390/molecules170911089
Received: 29 August 2012; in revised form: 10 September 2012 / Accepted: 11 September 2012 / Published: 14 September 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (484 KB)
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by , , , , , , ,  and
Molecules 2012, 17(9), 11026-11045; doi:10.3390/molecules170911026
Received: 1 June 2012; in revised form: 30 August 2012 / Accepted: 31 August 2012 / Published: 13 September 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (851 KB) | Supplementary Files
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by , ,  and
Molecules 2012, 17(9), 10026-10045; doi:10.3390/molecules170910026
Received: 27 June 2012; in revised form: 3 August 2012 / Accepted: 14 August 2012 / Published: 24 August 2012
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by , ,  and
Molecules 2012, 17(6), 7067-7082; doi:10.3390/molecules17067067
Received: 8 May 2012; in revised form: 24 May 2012 / Accepted: 4 June 2012 / Published: 8 June 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (395 KB)
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by , , , , , , ,  and
Molecules 2012, 17(6), 6519-6546; doi:10.3390/molecules17066519
Received: 28 April 2012; in revised form: 21 May 2012 / Accepted: 21 May 2012 / Published: 30 May 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (491 KB)
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Last update: 4 March 2014

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