Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation
AbstractHarmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of its synthetic anticancer-active derivatives to the genomic DNA from calf thymus and two synthetic 20-mer double helices, the poly(dG-dC)·poly(dG-dC) and the poly(dA-dT)·poly(dA-dT), by means of UV-Vis and circular dichroism (CD) spectroscopies. The data show that the DNA binding and stabilising properties of the investigated derivatives are base pair-dependent. These results could be used as a guide to design and develop further bioactive analogues. View Full-Text
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Pagano, B.; Caterino, M.; Filosa, R.; Giancola, C. Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation. Molecules 2017, 22, 1831.
Pagano B, Caterino M, Filosa R, Giancola C. Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation. Molecules. 2017; 22(11):1831.Chicago/Turabian Style
Pagano, Bruno; Caterino, Marco; Filosa, Rosanna; Giancola, Concetta. 2017. "Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation." Molecules 22, no. 11: 1831.
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