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Molecules 2016, 21(9), 1082; doi:10.3390/molecules21091082

DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization

Laboratoire de Synthèse et Physico-Chimie de Molécules d′Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 Route de Narbonne, Cedex 9, Toulouse 31062, France
Dedicated to our late colleague Dr. Aloysius Siriwardena.
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Authors to whom correspondence should be addressed.
Academic Editors: Ramon Eritja, Lajos Kovacs and Daniela Montesarchio
Received: 5 July 2016 / Revised: 8 August 2016 / Accepted: 10 August 2016 / Published: 23 August 2016
(This article belongs to the Collection New Frontiers in Nucleic Acid Chemistry)
View Full-Text   |   Download PDF [1251 KB, uploaded 23 August 2016]   |  

Abstract

Construction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5′-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react through a post synthetic CuACC reaction with either protected imidazolyl-, hydroxyl- or carboxyl-azide. Structural impacts of 5′-C(S)-functionalization were investigated to evaluate how 3WJ flexibility/stability is affected. View Full-Text
Keywords: three way junction; convertible nucleotide; CuACC; chemically modified oligonucleotides three way junction; convertible nucleotide; CuACC; chemically modified oligonucleotides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Addamiano, C.; Gerland, B.; Payrastre, C.; Escudier, J.-M. DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization. Molecules 2016, 21, 1082.

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