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Molecules 2012, 17(10), 12378-12392; doi:10.3390/molecules171012378
Article

Synthesis of a Cholesteryl-HEG Phosphoramidite Derivative and Its Application to Lipid-conjugates of the Anti-HIV 5'TGGGAG3' Hotoda’s Sequence

 and *
Received: 19 September 2012; in revised form: 16 October 2012 / Accepted: 17 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Nucleic Acid Analogs)
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Abstract: A novel phosphoramidite derivative of cholesterol, with an ether-linked hexaethylene glycol (HEG) spacer arm, has been obtained through simple and reproducible solid phase modified oligonucleotide synthesis manipulations. This building block and the known phosphoramidite derivative of 3b-(2-hydroxyethoxy)cholesterol have been exploited in standard oligonucleotide synthesis protocols for the preparation of 5'- conjugates of the G-quadruplex-forming 5'TGGGAG3' oligomer, known as the Hotoda’s sequence, to produce new potential anti-HIV agents.
Keywords: phosphoramidite; cholesterol; solid phase synthesis; anti-HIV G-rich oligonucleotides phosphoramidite; cholesterol; solid phase synthesis; anti-HIV G-rich oligonucleotides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Musumeci, D.; Montesarchio, D. Synthesis of a Cholesteryl-HEG Phosphoramidite Derivative and Its Application to Lipid-conjugates of the Anti-HIV 5'TGGGAG3' Hotoda’s Sequence. Molecules 2012, 17, 12378-12392.

AMA Style

Musumeci D, Montesarchio D. Synthesis of a Cholesteryl-HEG Phosphoramidite Derivative and Its Application to Lipid-conjugates of the Anti-HIV 5'TGGGAG3' Hotoda’s Sequence. Molecules. 2012; 17(10):12378-12392.

Chicago/Turabian Style

Musumeci, Domenica; Montesarchio, Daniela. 2012. "Synthesis of a Cholesteryl-HEG Phosphoramidite Derivative and Its Application to Lipid-conjugates of the Anti-HIV 5'TGGGAG3' Hotoda’s Sequence." Molecules 17, no. 10: 12378-12392.



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