Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives

doi:10.3390/molecules171012061

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Molecules 2012, 17(10), 12061-12071; doi:10.3390/molecules171012061

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Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives

Hyun Yi Cho¹, Sang Keun Woo^2,* and Gil Tae Hwang^1,*

¹ Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu 702-701, Korea ² Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, 75 Nowon-gil, Seoul 139-706, Korea

* Authors to whom correspondence should be addressed.

Received: 14 September 2012; in revised form: 3 October 2012 / Accepted: 10 October 2012 / Published: 15 October 2012

(This article belongs to the Special Issue Nucleic Acid Analogs)

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Abstract: We examined microenvironment-sensitive fluorescent 2′-deoxyuridines labeled with fluorene derivatives that exhibited solvent-dependent photophysical properties. The high sensitivity of the fluorescence shift and the nucleoside intensity dependence on solvent polarity provided information useful for estimating the polarity of the environment surrounding the fluorescent nucleoside.

Keywords: nucleosides; fluorene; fluorescence; dibenzofuran; dibenzothiophene

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Cite This Article

MDPI and ACS Style

Cho, H.Y.; Woo, S.K.; Hwang, G.T. Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives. Molecules 2012, 17, 12061-12071.

AMA Style

Cho HY, Woo SK, Hwang GT. Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives. Molecules. 2012; 17(10):12061-12071.

Chicago/Turabian Style

Cho, Hyun Y.; Woo, Sang K.; Hwang, Gil T. 2012. "Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives." Molecules 17, no. 10: 12061-12071.

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