Special Issue "Advances in the Research of Melatonin 2014"
Deadline for manuscript submissions: closed (31 July 2014)
Prof. Dr. Rudiger Hardeland
Institute of Zoology and Anthropology, University of Goettingen, Berliner Str. 28, D-37073 Goettingen, Germany
Considerable progress has been made during recent years in the research of melatonin and melatonergic signaling. This extends from the classic role of melatonin as a regulator of temporal processes in vertebrates to various other fields, such as actions in invertebrate animals, plants and unicellular organisms as well as various aspects of human health. The medicinal perspectives concern areas as different as gerontology, sleep research, mental disorders, immunology, oxidative stress including mitochondrial dysfunction, metabolic disorders and diseases. An increasing number of studies are dealing with the corresponding effects of synthetic melatonergic agonists, which differ with regard to duration of action, receptor affinity and metabolism. In some cases, the melatonergic actions are associated with properties such as serotonergic antagonists. Despite this novel complexity, the effects of melatonin and its synthetic analogs on the circadian system continues to be of particular interest, especially as well-functioning of both central and peripheral circadian oscillators is increasingly perceived to be of significant importance to health. Phasing and coordination of rhythms and support of circadian amplitudes seem to represent an area in which cellular oscillations and melatonergic actions are intertwined, with mutual support and synergism in its physiological outcome. The hope is that maintenance of these time structures might overcome, to a certain degree, pathophysiological changes caused by aging and diseases. Melatonin and its synthetic analogs may represent tools for achieving this objective. The numerous perspectives resulting from new findings justify a continuation of the special issue on Advances in the Research of Melatonin that started in 2013.
Prof. Dr. Rudiger Hardeland
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- antioxidative protection
- immune system
- melatonergic drugs
- mental disorders
- metabolic syndrome