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Int. J. Mol. Sci. 2015, 16(1), 1030-1042; doi:10.3390/ijms16011030

Melatonin and Female Hormone Secretion in Postmenopausal Overweight Women

Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Rudiger Hardeland
Received: 26 August 2014 / Accepted: 16 December 2014 / Published: 5 January 2015
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

Estrogen deficiency is considered to be the main cause of increased appetite and increased weight in postmenopausal women. In this period, reduced secretion of melatonin (MEL) was also observed. The aim of the study was to evaluate the secretion of melatonin, 17-β estradiol and follicle-stimulating hormone (FSH) in relation to body mass index (BMI) in pre- and postmenopausal women. The study included 90 women divided into three equal groups: group I (control)—women without menstrual disorders, group II—postmenopausal women without change in appetite and body weight, group III—postmenopausal women experiencing increased appetite and weight gain. In each patient, serum melatonin, 17-β-estradiol, FSH and urine a 6-sulfatoxymelatonin (aMT6s) were determined. Compared to the control group, the level of melatonin and estradiol was statistically lower. The FSH level was higher than in the groups of postmenopausal women. No significant correlation was found in all groups between the level of melatonin and the levels of estradiol and FSH. A negative correlation was found between aMT6s excretion and BMI, and a positive correlation between the level of FSH and BMI, mainly in overweight women. The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders. View Full-Text
Keywords: menopause; obesity; melatonin; 6-sulfatoxymelatonin; estradiol; follicle-stimulating hormone menopause; obesity; melatonin; 6-sulfatoxymelatonin; estradiol; follicle-stimulating hormone
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Walecka-Kapica, E.; Chojnacki, J.; Stępień, A.; Wachowska-Kelly, P.; Klupińska, G.; Chojnacki, C. Melatonin and Female Hormone Secretion in Postmenopausal Overweight Women. Int. J. Mol. Sci. 2015, 16, 1030-1042.

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