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Int. J. Mol. Sci. 2014, 15(9), 16848-16884; doi:10.3390/ijms150916848

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

1
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, Thailand
2
Center for Innovation Development and Technology Transfer, Faculty of Medical Technology, Mahidol University, Salaya, Nakornpathom 73170, Thailand
3
Center for Neuroscience and Department of Pharmacology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Received: 25 July 2014 / Revised: 3 September 2014 / Accepted: 12 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions. View Full-Text
Keywords: melatonin; brain aging; energy metabolism; epigenetics; autophagy; circadian rhythm; neurodegeneration; sirtuins melatonin; brain aging; energy metabolism; epigenetics; autophagy; circadian rhythm; neurodegeneration; sirtuins
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Jenwitheesuk, A.; Nopparat, C.; Mukda, S.; Wongchitrat, P.; Govitrapong, P. Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways. Int. J. Mol. Sci. 2014, 15, 16848-16884.

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