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Int. J. Mol. Sci. 2014, 15(9), 15924-15950; doi:10.3390/ijms150915924

Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders

Neurim Pharmaceuticals Ltd., 27 Habarzel St. Tel-Aviv 6971039, Israel
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Received: 21 July 2014 / Revised: 20 August 2014 / Accepted: 27 August 2014 / Published: 9 September 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
View Full-Text   |   Download PDF [722 KB, uploaded 9 September 2014]

Abstract

Several melatonin receptors agonists (ramelteon, prolonged-release melatonin, agomelatine and tasimelteon) have recently become available for the treatment of insomnia, depression and circadian rhythms sleep-wake disorders. The efficacy and safety profiles of these compounds in the treatment of the indicated disorders are reviewed. Accumulating evidence indicates that sleep-wake disorders and co-existing medical conditions are mutually exacerbating. This understanding has now been incorporated into the new Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). Therefore, when evaluating the risk/benefit ratio of sleep drugs, it is pertinent to also evaluate their effects on wake and comorbid condition. Beneficial effects of melatonin receptor agonists on comorbid neurological, psychiatric, cardiovascular and metabolic symptomatology beyond sleep regulation are also described. The review underlines the beneficial value of enhancing physiological sleep in comorbid conditions. View Full-Text
Keywords: insomnia comorbid; sleep; melatonin receptors agonists insomnia comorbid; sleep; melatonin receptors agonists
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Laudon, M.; Frydman-Marom, A. Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders. Int. J. Mol. Sci. 2014, 15, 15924-15950.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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