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Int. J. Mol. Sci. 2014, 15(12), 22320-22330; doi:10.3390/ijms151222320

Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum

1
Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São, São Paulo 05508-900, Brazil
2
Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil
3
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA
*
Author to whom correspondence should be addressed.
Received: 25 August 2014 / Revised: 11 September 2014 / Accepted: 16 October 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions. Previously, we reported a melatonin-induced upregulation of gene expression related to ubiquitin/proteasome system (UPS) in Plasmodium falciparum, the human malaria parasite, and that P. falciparum protein kinase 7 influences this process. This implies a role of melatonin, an indolamine, in modulating intraerythrocytic development of the parasite. In this report we demonstrate by qPCR analysis, that melatonin induces gene upregulation in nine out of fourteen genes of the UPS, consisting of the same set of genes previously reported, between 4 to 5 h after melatonin treatment. We demonstrate that melatonin causes a temporally controlled gene expression of UPS members. View Full-Text
Keywords: melatonin; ubiquitin-proteasome-system; Plasmodium falciparum; malaria melatonin; ubiquitin-proteasome-system; Plasmodium falciparum; malaria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Koyama, F.C.; Azevedo, M.F.; Budu, A.; Chakrabarti, D.; Garcia, C.R.S. Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum. Int. J. Mol. Sci. 2014, 15, 22320-22330.

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