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Int. J. Mol. Sci. 2014, 15(11), 20789-20799; doi:10.3390/ijms151120789

Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis

1
Department of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Marine Campus of International Excellence (CEIMAR), Agrifood Campus of International Excellence (ceiA3), E-11510 Puerto Real, Spain
2
Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University of Madrid, E-28040 Madrid, Spain
3
IEO, Spanish Institute of Oceanography, Santander Oceanographic Centre, Promontorio de San Martín, s/n, P.O. Box 240, E-39080 Santander, Spain
4
Aragó Laboratory—UMR7628 (CNRS and UPMC) and GDR2821 (CNRS/Ifremer), F-66651 Banyuls/Mer, France
5
INMAR-CACYTMAR Research Institutes, Puerto Real University Campus, E-11510 Puerto Real, Spain
Present address: Department of Fish Physiology and Biotechnology, Institute of Aquaculture of Torre de la Sal, Spanish National Research Council (CSIC), Torre de la Sal, Ribera de Cabanes, E-12595 Castellón, Spain
*
Author to whom correspondence should be addressed.
Received: 29 July 2014 / Revised: 31 October 2014 / Accepted: 3 November 2014 / Published: 13 November 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

Melatonin actions are mediated through G protein-coupled transmembrane receptors. Recently, mt1, mt2, and mel1c melatonin receptors were cloned in the Senegalese sole. Here, their day-night and developmental expressions were analyzed by quantitative PCR. These results revealed distinct expression patterns of each receptor through development. mel1c transcripts were more abundant in unfertilized ovulated oocytes and declined during embryonic development. mt1 and mt2 expression was higher at the earliest stages (2–6 days post-fertilization), decreasing before (mt2) or during (mt1) metamorphosis. Only mt1 and mel1c expression exhibited day-night variations, with higher nocturnal mRNA levels. These results suggest different roles and transcriptional regulation of these melatonin receptors during flatfish development and metamorphosis. View Full-Text
Keywords: melatonin receptors; development; metamorphosis; flatfish melatonin receptors; development; metamorphosis; flatfish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lan-Chow-Wing, O.; Confente, F.; Herrera-Pérez, P.; Isorna, E.; Chereguini, O.; Rendón, M.C.; Falcón, J.; Muñoz-Cueto, J.A. Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis. Int. J. Mol. Sci. 2014, 15, 20789-20799.

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