Special Issue "Advances in the Research of Melatonin"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (28 February 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Rudiger Hardeland
Institute of Zoology and Anthropology, University of Goettingen, Berliner Str. 28, D-37073 Goettingen, Germany
E-Mail: rhardel@gwdg.de

Special Issue Information

Dear Colleagues,

Accumulating evidence indicates an important role of melatonin and melatonergic signaling for the well-functioning of a body. Both physiological and psychological impairments can be associated with decreases of melatonin levels, as observed in the course of aging or as a consequence of various diseases and disorders. The multiplicity of possible changes reflects the extraordinary pleiotropy of this hormone. The association of deviations in melatonergic signaling with mental and metabolic disorders, in particular, diabetes type 2, is supported by knockouts and polymorphisms of genes involved in melatonin biosynthesis or signaling. An overlap with similar findings concerning genes of circadian oscillators indicates a significant chronobiological role of melatonin in the maintenance of health. High nocturnal levels of melatonin, which imply large amplitudes of the melatonin rhythm, synchronize other rhythms with external cycles and within the circadian multioscillator system. They support the maintenance of high amplitudes of peripheral rhythms, as shown by melatonin deficiency. They have also been interpreted as an indicator of youthfulness. Conversely, the decline of nocturnal melatonin leads to numerous undesired changes, including impairments in both detoxification and production of reactive oxygen and nitrogen species, increased susceptibility to these reactive compounds, mitochondrial dysfunction, reductions in immune functions, sleep disturbances and, eventually, mood disorders. To overcome these problems, prolonged-release formulations of melatonin and various synthetic melatonergic agonists have been developed, some of which combine melatonergic signaling with additional properties of possible value in the treatment of depressive symptoms and metabolic disorders.

Prof. Dr. Rudiger Hardeland
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF.

Keywords

  • aging
  • antioxidative protection
  • bipolar disorder
  • chronobiotic
  • diabetes
  • immune system
  • melatonergic drugs
  • metabolic syndrome
  • seasonal affective disorder
  • sleep

Related Special Issue

Published Papers (27 papers)

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Displaying article 1-27
p. 20508-20542
by , , , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20508-20542; doi:10.3390/ijms141020508
Received: 6 August 2013; in revised form: 3 September 2013 / Accepted: 13 September 2013 / Published: 14 October 2013
Show/Hide Abstract | Cited by 9 | PDF Full-text (301 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 18385-18406
by  and
Int. J. Mol. Sci. 2013, 14(9), 18385-18406; doi:10.3390/ijms140918385
Received: 2 June 2013; in revised form: 16 July 2013 / Accepted: 26 August 2013 / Published: 6 September 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (1366 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 13704-13718
by ,  and
Int. J. Mol. Sci. 2013, 14(7), 13704-13718; doi:10.3390/ijms140713704
Received: 19 May 2013; in revised form: 23 June 2013 / Accepted: 25 June 2013 / Published: 1 July 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (765 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 12550-12562
by , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 12550-12562; doi:10.3390/ijms140612550
Received: 5 March 2013; in revised form: 22 April 2013 / Accepted: 16 May 2013 / Published: 14 June 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (604 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 12458-12483
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 12458-12483; doi:10.3390/ijms140612458
Received: 17 March 2013; in revised form: 22 May 2013 / Accepted: 22 May 2013 / Published: 13 June 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (279 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 11742-11766
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11742-11766; doi:10.3390/ijms140611742
Received: 28 February 2013; in revised form: 15 May 2013 / Accepted: 16 May 2013 / Published: 31 May 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (532 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 11259-11276
by , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11259-11276; doi:10.3390/ijms140611259
Received: 22 March 2013; in revised form: 16 May 2013 / Accepted: 16 May 2013 / Published: 28 May 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (868 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 11208-11223
by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11208-11223; doi:10.3390/ijms140611208
Received: 27 February 2013; in revised form: 28 April 2013 / Accepted: 20 May 2013 / Published: 27 May 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (319 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 10063-10074
by ,  and
Int. J. Mol. Sci. 2013, 14(5), 10063-10074; doi:10.3390/ijms140510063
Received: 22 March 2013; in revised form: 29 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
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(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 9379-9395
by , , ,  and
Int. J. Mol. Sci. 2013, 14(5), 9379-9395; doi:10.3390/ijms14059379
Received: 28 February 2013; in revised form: 15 April 2013 / Accepted: 16 April 2013 / Published: 29 April 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (2530 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 8924-8947
by ,  and
Int. J. Mol. Sci. 2013, 14(5), 8924-8947; doi:10.3390/ijms14058924
Received: 8 March 2013; in revised form: 10 April 2013 / Accepted: 11 April 2013 / Published: 25 April 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (308 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 8948-8962
by , , , , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(5), 8948-8962; doi:10.3390/ijms14058948
Received: 16 March 2013; in revised form: 14 April 2013 / Accepted: 15 April 2013 / Published: 25 April 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (378 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 9037-9050
by  and
Int. J. Mol. Sci. 2013, 14(5), 9037-9050; doi:10.3390/ijms14059037
Received: 19 February 2013; in revised form: 9 April 2013 / Accepted: 10 April 2013 / Published: 25 April 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (195 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 8638-8683
by , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 8638-8683; doi:10.3390/ijms14048638
Received: 1 March 2013; in revised form: 6 April 2013 / Accepted: 7 April 2013 / Published: 22 April 2013
Show/Hide Abstract | Cited by 21 | PDF Full-text (567 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 8093-8121
by , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 8093-8121; doi:10.3390/ijms14048093
Received: 7 March 2013; in revised form: 28 March 2013 / Accepted: 28 March 2013 / Published: 12 April 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (3810 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 7979-7999
by , ,  and
Int. J. Mol. Sci. 2013, 14(4), 7979-7999; doi:10.3390/ijms14047979
Received: 15 January 2013; in revised form: 26 March 2013 / Accepted: 27 March 2013 / Published: 11 April 2013
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(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 7603-7616
by , ,  and
Int. J. Mol. Sci. 2013, 14(4), 7603-7616; doi:10.3390/ijms14047603
Received: 11 March 2013; in revised form: 24 March 2013 / Accepted: 26 March 2013 / Published: 8 April 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (590 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 7231-7272
by , ,  and
Int. J. Mol. Sci. 2013, 14(4), 7231-7272; doi:10.3390/ijms14047231
Received: 25 February 2013; Accepted: 27 March 2013 / Published: 2 April 2013
Show/Hide Abstract | Cited by 18 | PDF Full-text (3236 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 6981-7015
by ,  and
Int. J. Mol. Sci. 2013, 14(4), 6981-7015; doi:10.3390/ijms14046981
Received: 21 February 2013; in revised form: 7 March 2013 / Accepted: 11 March 2013 / Published: 27 March 2013
Show/Hide Abstract | Cited by 10 | PDF Full-text (572 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 6597-6613
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 6597-6613; doi:10.3390/ijms14046597
Received: 5 March 2013; in revised form: 18 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
Show/Hide Abstract | Cited by 11 | PDF Full-text (1623 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 6345-6358
by , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(3), 6345-6358; doi:10.3390/ijms14036345
Received: 7 January 2013; in revised form: 13 March 2013 / Accepted: 13 March 2013 / Published: 19 March 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (531 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 5817-5841
by
Int. J. Mol. Sci. 2013, 14(3), 5817-5841; doi:10.3390/ijms14035817
Received: 17 February 2013; in revised form: 1 March 2013 / Accepted: 4 March 2013 / Published: 12 March 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (347 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 5380-5401
by , , ,  and
Int. J. Mol. Sci. 2013, 14(3), 5380-5401; doi:10.3390/ijms14035380
Received: 17 February 2013; in revised form: 25 February 2013 / Accepted: 25 February 2013 / Published: 6 March 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (304 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 3901-3920
by , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 3901-3920; doi:10.3390/ijms14023901
Received: 22 January 2013; in revised form: 31 January 2013 / Accepted: 4 February 2013 / Published: 14 February 2013
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(This article belongs to the Special Issue Advances in the Research of Melatonin)
p. 2573-2589
by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 2573-2589; doi:10.3390/ijms14022573
Received: 23 November 2012; in revised form: 23 December 2012 / Accepted: 16 January 2013 / Published: 28 January 2013
Show/Hide Abstract | Cited by 4 | PDF Full-text (595 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 2502-2514
by , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 2502-2514; doi:10.3390/ijms14022502
Received: 24 December 2012; in revised form: 15 January 2013 / Accepted: 22 January 2013 / Published: 25 January 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (708 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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p. 2410-2430
by , ,  and
Int. J. Mol. Sci. 2013, 14(2), 2410-2430; doi:10.3390/ijms14022410
Received: 5 December 2012; in revised form: 14 January 2013 / Accepted: 15 January 2013 / Published: 24 January 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (747 KB) | HTML Full-text | XML Full-text
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Last update: 7 August 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert