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Int. J. Mol. Sci. 2014, 15(10), 18484-18495; doi:10.3390/ijms151018484

Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective

1
Departments of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
2
Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
3
Department of Traditional Chinese Medicine, Chang Gung University, Linkow 244, Taiwan
*
Author to whom correspondence should be addressed.
Received: 13 July 2014 / Revised: 4 September 2014 / Accepted: 25 September 2014 / Published: 14 October 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

Melatonin is an endogenously produced indoleamine and secreted by the pineal gland. Melatonin has pleiotropic bioactivities and is involved in epigenetic regulation. Suboptimal conditions during maternal and perinatal phases can elicit epigenetic regulation of genes for nephrogenesis and reset physiological responses to develop programmed hypertension. This review discusses the early utility of melatonin to prevent programmed hypertension in later life by epigenetic regulation in the kidney, with an emphasis on: (1) the role of melatonin in epigenetic regulation; (2) the beneficial effects of melatonin on programmed hypertension; (3) epigenetic regulation of maternal melatonin therapy in different developmental windows of offspring kidneys analyzed by whole-genome RNA next-generation sequencing; and (4) current blocks in the application of melatonin in preventing programmed hypertension. View Full-Text
Keywords: developmental programming; epigenetic regulation; hypertension; melatonin; next generation sequencing; oxidative stress; renin-angiotensin system developmental programming; epigenetic regulation; hypertension; melatonin; next generation sequencing; oxidative stress; renin-angiotensin system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tain, Y.-L.; Huang, L.-T.; Chan, J.Y.H. Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective. Int. J. Mol. Sci. 2014, 15, 18484-18495.

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