Next Article in Journal
Non-Coding RNAs and Lipid Metabolism
Next Article in Special Issue
Melatonin Suppresses Hypoxia-Induced Migration of HUVECs via Inhibition of ERK/Rac1 Activation
Previous Article in Journal
The Mitochondrion-Located Protein OsB12D1 Enhances Flooding Tolerance during Seed Germination and Early Seedling Growth in Rice
Previous Article in Special Issue
Diurnal Profiles of Melatonin Synthesis-Related Indoles, Catecholamines and Their Metabolites in the Duck Pineal Organ
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(8), 13482-13493; doi:10.3390/ijms150813482

Melatonin and Atopy: Role in Atopic Dermatitis and Asthma

1
Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy
2
Unit of Paediatric Genetics and Immunology, Department of Paediatrics, University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy
3
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 40729, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 June 2014 / Revised: 22 July 2014 / Accepted: 22 July 2014 / Published: 4 August 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
View Full-Text   |   Download PDF [663 KB, uploaded 4 August 2014]

Abstract

Melatonin may have important immunostimulatory actions in allergic diseases, in addition to its well-known antioxidant and cytoprotective effects in several inflammatory conditions. The activation of the immune system leads to free radical production associated with decreased melatonin levels and depressed antioxidant enzyme activities in several inflammatory diseases. Many skin disorders, including atopic dermatitis, are accompanied by infiltration and activation of mast cells, which release vasoactive and proinflammatory mediators. Experimental data suggest that melatonin inhibits development of atopic eczema and reduces serum total IgE and IL-4. Allergic asthma is a condition characterized by bronchial hyperresponsiveness and the presence of IgE antibodies in response to inhaled allergens; often there is also enhanced total serum IgE levels. Melatonin regulates smooth muscle tone and influences the immune response. Melatonin may, however, act as a pro-inflammatory agent in asthma leading to bronchial constriction. The safety of melatonin as a sleep-inducing agent has been confirmed in asthmatic subjects, but its routine use is not recommended in bronchial asthma. This review summarizes what is known about the role of melatonin as an immunomodulatory agent in asthma and atopic eczema. View Full-Text
Keywords: melatonin; allergy; bronchial asthma; atopic eczema melatonin; allergy; bronchial asthma; atopic eczema
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marseglia, L.; D'Angelo, G.; Manti, S.; Salpietro, C.; Arrigo, T.; Barberi, I.; Reiter, R.J.; Gitto, E. Melatonin and Atopy: Role in Atopic Dermatitis and Asthma. Int. J. Mol. Sci. 2014, 15, 13482-13493.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top