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Int. J. Mol. Sci. 2014, 15(7), 12107-12118; doi:10.3390/ijms150712107

Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)

1
Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100091, China
2
Animal Husbandry Station of Beijing, Beijing 100101, China
3
Department of Cellular & Structural Biology, the UT Health Science Center, San Antonio, TX 78229, USA
4
Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University (Chengdu Campus), Chengdu 611130, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 21 May 2014 / Revised: 19 June 2014 / Accepted: 30 June 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Abstract

In this study, the effects of melatonin (MT) on superovulation and reproductive hormones (melatonin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL) were investigated in female sika deer. Different doses (40 or 80 mg/animal) of melatonin were subcutaneously implanted into deer before the breeding season. Exogenous melatonin administration significantly elevated the serum FSH levels at the time of insemination compared with levels in control animals. During superovulation, the serum LH levels in donor sika deer reached their highest values (7.1 ± 2.04 ng/mL) at the point of insemination, compared with the baseline levels (4.98 ± 0.07 ng/mL) in control animals. This high level of LH was sustained until the day of embryo recovery. In contrast, the serum levels of PRL in the 80 mg of melatonin-treated group were significantly lower than those of control deer. The average number of corpora lutea in melatonin-treated deer was significantly higher than that of the control (p < 0.05). The average number of embryos in the deer treated with 40 mg of melatonin was higher than that of the control; however, this increase did not reach significant difference (p > 0.05), which may be related to the relatively small sample size. In addition, embryonic development in melatonin-treated groups was delayed.
Keywords: melatonin; superovulation; FSH; LH; PRL; sika melatonin; superovulation; FSH; LH; PRL; sika
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, L.; Zhuo, Z.-Y.; Shi, W.-Q.; Tan, D.-X.; Gao, C.; Tian, X.-Z.; Zhang, L.; Zhou, G.-B.; Zhu, S.-E.; Yun, P.; Liu, G.-S. Melatonin Promotes Superovulation in Sika Deer (Cervus nippon). Int. J. Mol. Sci. 2014, 15, 12107-12118.

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