Int. J. Mol. Sci. 2014, 15(7), 12107-12118; doi:10.3390/ijms150712107
Article

Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)

1,2,†email, 1,†email, 2email, 3email, 1email, 1email, 1email, 4email, 1email, 2,* email and 1,* email
Received: 21 May 2014; in revised form: 19 June 2014 / Accepted: 30 June 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this study, the effects of melatonin (MT) on superovulation and reproductive hormones (melatonin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL) were investigated in female sika deer. Different doses (40 or 80 mg/animal) of melatonin were subcutaneously implanted into deer before the breeding season. Exogenous melatonin administration significantly elevated the serum FSH levels at the time of insemination compared with levels in control animals. During superovulation, the serum LH levels in donor sika deer reached their highest values (7.1 ± 2.04 ng/mL) at the point of insemination, compared with the baseline levels (4.98 ± 0.07 ng/mL) in control animals. This high level of LH was sustained until the day of embryo recovery. In contrast, the serum levels of PRL in the 80 mg of melatonin-treated group were significantly lower than those of control deer. The average number of corpora lutea in melatonin-treated deer was significantly higher than that of the control (p < 0.05). The average number of embryos in the deer treated with 40 mg of melatonin was higher than that of the control; however, this increase did not reach significant difference (p > 0.05), which may be related to the relatively small sample size. In addition, embryonic development in melatonin-treated groups was delayed.
Keywords: melatonin; superovulation; FSH; LH; PRL; sika
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MDPI and ACS Style

Wang, L.; Zhuo, Z.-Y.; Shi, W.-Q.; Tan, D.-X.; Gao, C.; Tian, X.-Z.; Zhang, L.; Zhou, G.-B.; Zhu, S.-E.; Yun, P.; Liu, G.-S. Melatonin Promotes Superovulation in Sika Deer (Cervus nippon). Int. J. Mol. Sci. 2014, 15, 12107-12118.

AMA Style

Wang L, Zhuo Z-Y, Shi W-Q, Tan D-X, Gao C, Tian X-Z, Zhang L, Zhou G-B, Zhu S-E, Yun P, Liu G-S. Melatonin Promotes Superovulation in Sika Deer (Cervus nippon). International Journal of Molecular Sciences. 2014; 15(7):12107-12118.

Chicago/Turabian Style

Wang, Liang; Zhuo, Zhi-Yong; Shi, Wen-Qing; Tan, Dun-Xian; Gao, Chao; Tian, Xiu-Zhi; Zhang, Lu; Zhou, Guang-Bin; Zhu, Shi-En; Yun, Peng; Liu, Guo-Shi. 2014. "Melatonin Promotes Superovulation in Sika Deer (Cervus nippon)." Int. J. Mol. Sci. 15, no. 7: 12107-12118.


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