Special Issue "Oxidative Stress in Cardiovascular Disease"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (30 May 2013)

Special Issue Editors

Guest Editor
Dr. Francis J. Miller Jr.
Departments of Internal Medicine and Anatomy and Cell Biology, University of Iowa, Veterans Affairs Medical Center, Iowa City, Iowa, USA
Website: http://www.int-med.uiowa.edu/divisions/cardiology/Directory/FrancisMiller.html
E-Mail: francis-miller@uiowa.edu
Interests: atherosclerosis; reactive oxygen species; oxidative stress; smooth muscle cells; NADPH oxidases; restenosis; redox signaling

Guest Editor
Dr. Gabor Csanyi
Vascular Medicine Institute, E1228-1B BST, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Website: http://www.vmi.pitt.edu/Csanyi.html
E-Mail: gac22@pitt.edu
Interests: oxidative stress, reactive oxygen species, NADPH oxidase, cardiovascular disease, vascular tone dysfunction, thrombospondins, nitric oxide, prostanoids, and EDHF

Special Issue Information

Dear Colleagues,

Cardiovascular disease is the leading cause of mortality and the most expensive health condition in the United States. Animal and human data implicate increased levels of reactive oxygen species (ROS) associated with oxidative stress in the pathogenesis of cardiovascular disease. Whereas ROS are essential for normal cellular processes, the molecular effects of increased ROS include the oxidation of DNA, RNA, lipids and proteins resulting in the dysregulation of ion channels, signaling pathways and transcription factors. However, we still do not have a complete understanding of the underlying mechanisms and consequences of increased ROS generation in cardiovascular tissue. Reducing oxidative stress represents a promising approach for prevention and treatment of cardiovascular disease. However, in numerous clinical trials, antioxidant supplementation failed to reduce cardiovascular morbidity or mortality. Therefore, alternative strategies are to achieve targeted delivery of antioxidants or to inhibit specific enzymatic sources of ROS, which include the mitochondria,  NADPH oxidases, xanthine oxidase, lipooxygenase, cyclooxygenase, and nitric oxide synthase. This special issue will focus on the causes and consequence of oxidative stress in cardiovascular disease and explore emerging treatment strategies.

Prof. Dr. Francis Miller, Jr.
Dr. Gabor Csanyi
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF.

Keywords

  • oxidative stress, reactive oxygen species
  • heart disease, myocardial infarction, ischemia/reperfusion, preconditioning
  • vascular disease, atherosclerosis, hypertension, restenosis, stroke, thrombosis
  • biomarkers of oxidative stress
  • redox-mediated signaling
  • transcription factors, antioxidant response elements
  • antioxidant therapy

Related Special Issue

Published Papers (31 papers)

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p. 6002-6008
by  and
Int. J. Mol. Sci. 2014, 15(4), 6002-6008; doi:10.3390/ijms15046002
Received: 7 March 2014; in revised form: 25 March 2014 / Accepted: 31 March 2014 / Published: 9 April 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 23893-23909
by , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 23893-23909; doi:10.3390/ijms141223893
Received: 18 September 2013; in revised form: 11 November 2013 / Accepted: 21 November 2013 / Published: 9 December 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 23471-23491
by , , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 23471-23491; doi:10.3390/ijms141223471
Received: 5 September 2013; in revised form: 8 November 2013 / Accepted: 13 November 2013 / Published: 28 November 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 23011-23032
by , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 23011-23032; doi:10.3390/ijms141123011
Received: 3 August 2013; in revised form: 30 October 2013 / Accepted: 1 November 2013 / Published: 20 November 2013
Show/Hide Abstract | Cited by 4 | PDF Full-text (535 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 22274-22330
by
Int. J. Mol. Sci. 2013, 14(11), 22274-22330; doi:10.3390/ijms141122274
Received: 29 June 2013; in revised form: 23 October 2013 / Accepted: 24 October 2013 / Published: 13 November 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (482 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 22042-22051
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 22042-22051; doi:10.3390/ijms141122042
Received: 16 August 2013; in revised form: 28 October 2013 / Accepted: 30 October 2013 / Published: 7 November 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (231 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 21525-21550
by , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 21525-21550; doi:10.3390/ijms141121525
Received: 22 August 2013; in revised form: 14 October 2013 / Accepted: 18 October 2013 / Published: 30 October 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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p. 20845-20876
by  and
Int. J. Mol. Sci. 2013, 14(10), 20845-20876; doi:10.3390/ijms141020845
Received: 29 August 2013; in revised form: 2 October 2013 / Accepted: 8 October 2013 / Published: 17 October 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (586 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 20597-20613
by ,  and Jr.
Int. J. Mol. Sci. 2013, 14(10), 20597-20613; doi:10.3390/ijms141020597
Received: 24 July 2013; in revised form: 20 September 2013 / Accepted: 8 October 2013 / Published: 15 October 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (635 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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p. 20220-20235
by , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20220-20235; doi:10.3390/ijms141020220
Received: 8 August 2013; in revised form: 28 August 2013 / Accepted: 16 September 2013 / Published: 11 October 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (3072 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 19891-19910
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 19891-19910; doi:10.3390/ijms141019891
Received: 8 August 2013; in revised form: 5 September 2013 / Accepted: 5 September 2013 / Published: 1 October 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (457 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 19792-19804
by , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 19792-19804; doi:10.3390/ijms141019792
Received: 19 August 2013; in revised form: 16 September 2013 / Accepted: 17 September 2013 / Published: 30 September 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 18861-18880
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 18861-18880; doi:10.3390/ijms140918861
Received: 31 May 2013; in revised form: 5 August 2013 / Accepted: 5 September 2013 / Published: 13 September 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (1376 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 18640-18656
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 18640-18656; doi:10.3390/ijms140918640
Received: 12 August 2013; in revised form: 30 August 2013 / Accepted: 2 September 2013 / Published: 10 September 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (2207 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 17664-17679
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17664-17679; doi:10.3390/ijms140917664
Received: 14 June 2013; in revised form: 30 July 2013 / Accepted: 16 August 2013 / Published: 28 August 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (513 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 17553-17572
by , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17553-17572; doi:10.3390/ijms140917553
Received: 1 July 2013; in revised form: 9 August 2013 / Accepted: 12 August 2013 / Published: 27 August 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 17238-17255
by , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17238-17255; doi:10.3390/ijms140917238
Received: 3 June 2013; in revised form: 12 August 2013 / Accepted: 13 August 2013 / Published: 22 August 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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p. 17319-17346
by , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17319-17346; doi:10.3390/ijms140917319
Received: 27 June 2013; in revised form: 25 July 2013 / Accepted: 26 July 2013 / Published: 22 August 2013
Show/Hide Abstract | Cited by 17 | PDF Full-text (731 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 17017-17028
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 17017-17028; doi:10.3390/ijms140817017
Received: 27 May 2013; in revised form: 26 July 2013 / Accepted: 9 August 2013 / Published: 19 August 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (1073 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 16258-16279
by , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 16258-16279; doi:10.3390/ijms140816258
Received: 30 May 2013; in revised form: 23 July 2013 / Accepted: 30 July 2013 / Published: 6 August 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (277 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 15724-15739
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 15724-15739; doi:10.3390/ijms140815724
Received: 27 May 2013; in revised form: 26 June 2013 / Accepted: 8 July 2013 / Published: 29 July 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 15212-15232
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 15212-15232; doi:10.3390/ijms140815212
Received: 3 June 2013; in revised form: 15 June 2013 / Accepted: 18 June 2013 / Published: 24 July 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 15105-15120
by , ,  and
Int. J. Mol. Sci. 2013, 14(7), 15105-15120; doi:10.3390/ijms140715105
Received: 31 May 2013; in revised form: 4 July 2013 / Accepted: 10 July 2013 / Published: 19 July 2013
Show/Hide Abstract | Cited by 4 | PDF Full-text (577 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 13909-13930
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 13909-13930; doi:10.3390/ijms140713909
Received: 23 May 2013; in revised form: 19 June 2013 / Accepted: 21 June 2013 / Published: 4 July 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 12696-12713
by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 12696-12713; doi:10.3390/ijms140612696
Received: 10 April 2013; in revised form: 11 May 2013 / Accepted: 5 June 2013 / Published: 17 June 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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p. 10465-10482
by , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(5), 10465-10482; doi:10.3390/ijms140510465
Received: 5 March 2013; in revised form: 24 April 2013 / Accepted: 9 May 2013 / Published: 21 May 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 10107-10121
by ,  and
Int. J. Mol. Sci. 2013, 14(5), 10107-10121; doi:10.3390/ijms140510107
Received: 11 March 2013; in revised form: 16 April 2013 / Accepted: 29 April 2013 / Published: 10 May 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 9408-9423
by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(5), 9408-9423; doi:10.3390/ijms14059408
Received: 19 March 2013; in revised form: 15 April 2013 / Accepted: 16 April 2013 / Published: 29 April 2013
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 8062-8072
by , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 8062-8072; doi:10.3390/ijms14048062
Received: 20 January 2013; in revised form: 1 April 2013 / Accepted: 1 April 2013 / Published: 12 April 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (373 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 6903-6919
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 6903-6919; doi:10.3390/ijms14046903
Received: 30 January 2013; in revised form: 8 March 2013 / Accepted: 19 March 2013 / Published: 27 March 2013
Show/Hide Abstract | Cited by 11 | PDF Full-text (347 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
p. 6746-6756
by , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 6746-6756; doi:10.3390/ijms14046746
Received: 9 December 2012; in revised form: 2 March 2013 / Accepted: 16 March 2013 / Published: 26 March 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (1757 KB) | HTML Full-text | XML Full-text
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Last update: 13 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert