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Int. J. Mol. Sci. 2013, 14(9), 17238-17255; doi:10.3390/ijms140917238
Article

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

1,2,†
, 1,†
, 1,2
 and 1,2,*
Received: 3 June 2013; in revised form: 12 August 2013 / Accepted: 13 August 2013 / Published: 22 August 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: The current nutritional habits and lifestyles of modern societies favor energy overloads and a diminished physical activity, which may produce serious clinical disturbances and excessive weight gain. In order to investigate the mechanisms by which the environmental factors interact with molecular mechanisms in obesity, a pathway analysis was performed to identify genes differentially expressed in subcutaneous abdominal adipose tissue (SCAAT) from obese compared to lean male (21–35 year-old) subjects living in similar obesogenic conditions: habitual high fat dietary intake and moderate physical activity. Genes involved in inflammation (ALCAM, CTSB, C1S, YKL-40, MIF, SAA2), extracellular matrix remodeling (MMP9, PALLD), angiogenesis (EGFL6, leptin) and oxidative stress (AKR1C3, UCHL1, HSPB7 and NQO1) were upregulated; whereas apoptosis, signal transcription (CITED 2 and NR3C1), cell control and cell cycle-related genes were downregulated. Interestingly, the expression of some of these genes (C1S, SAA2, ALCAM, CTSB, YKL-40 and tenomodulin) was found to be associated with some relevant metabolic syndrome features. The obese group showed a general upregulation in the expression of inflammatory, oxidative stress, extracellular remodeling and angiogenic genes compared to lean subjects, suggesting that a given genetic background in an obesogenic environment could underlie the resistance to gaining weight and obesity-associated manifestations.
Keywords: metabolic syndrome; microarray; inflammation; oxidative stress; subcutaneous adipose tissue metabolic syndrome; microarray; inflammation; oxidative stress; subcutaneous adipose tissue
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

González-Muniesa, P.; Marrades, M.P.; Martínez, J.A.; Moreno-Aliaga, M.J. Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background. Int. J. Mol. Sci. 2013, 14, 17238-17255.

AMA Style

González-Muniesa P, Marrades MP, Martínez JA, Moreno-Aliaga MJ. Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background. International Journal of Molecular Sciences. 2013; 14(9):17238-17255.

Chicago/Turabian Style

González-Muniesa, Pedro; Marrades, María P.; Martínez, José A.; Moreno-Aliaga, María J. 2013. "Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background." Int. J. Mol. Sci. 14, no. 9: 17238-17255.


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