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The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease
Department of Pharmacology, Faculty of Dentistry, Mahidol University, 6 Yothe Road, Rajthevee, Bangkok 10400, Thailand
Division of Brain Science, Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
* Author to whom correspondence should be addressed.
Received: 23 May 2013; in revised form: 19 June 2013 / Accepted: 21 June 2013 / Published: 4 July 2013
Abstract: Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone.
Keywords: edaravone; cardiovascular disease; free radical scavenger
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Kikuchi, K.; Tancharoen, S.; Takeshige, N.; Yoshitomi, M.; Morioka, M.; Murai, Y.; Tanaka, E. The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease. Int. J. Mol. Sci. 2013, 14, 13909-13930.
Kikuchi K, Tancharoen S, Takeshige N, Yoshitomi M, Morioka M, Murai Y, Tanaka E. The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease. International Journal of Molecular Sciences. 2013; 14(7):13909-13930.
Kikuchi, Kiyoshi; Tancharoen, Salunya; Takeshige, Nobuyuki; Yoshitomi, Munetake; Morioka, Motohiro; Murai, Yoshinaka; Tanaka, Eiichiro. 2013. "The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease." Int. J. Mol. Sci. 14, no. 7: 13909-13930.