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Oxidative Stress and MicroRNAs in Vascular Diseases
Istituto Dermopatico del'Immacolata-IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy
Policlinico San Donato-IRCCS, Molecular Cardiology Laboratory, Via Morandi 30, San Donato Milanese, Milan 20097, Italy
Division of Cardiovascular Epigenetics, Department of Cardiology, Internal Medicine Clinic III, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany
* Author to whom correspondence should be addressed.
Received: 27 June 2013; in revised form: 25 July 2013 / Accepted: 26 July 2013 / Published: 22 August 2013
Abstract: Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis. Indeed, increased reactive oxygen species (ROS) production is known to impair endothelial and vascular smooth muscle cell functions, contributing to the development of cardiovascular diseases. MicroRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of target messenger RNAs. They have been shown to be modulated in most biological processes, including in cellular responses to redox imbalance. In particular, miR-200 family members play a crucial role in oxidative-stress dependent endothelial dysfunction, as well as in cardiovascular complications of diabetes and obesity. In addition, different miRNAs, such as miR-210, have been demonstrated to play a key role in mitochondrial metabolism, therefore modulating ROS production and sensitivity. In this review, we will discuss miRNAs modulated by ROS or involved in ROS production, and implicated in vascular diseases in which redox imbalance has a pathogenetic role.
Keywords: microRNAs; oxidative stress; vascular diseases; mitochondrial dysfunction; endothelial dysfunction
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MDPI and ACS Style
Magenta, A.; Greco, S.; Gaetano, C.; Martelli, F. Oxidative Stress and MicroRNAs in Vascular Diseases. Int. J. Mol. Sci. 2013, 14, 17319-17346.
Magenta A, Greco S, Gaetano C, Martelli F. Oxidative Stress and MicroRNAs in Vascular Diseases. International Journal of Molecular Sciences. 2013; 14(9):17319-17346.
Magenta, Alessandra; Greco, Simona; Gaetano, Carlo; Martelli, Fabio. 2013. "Oxidative Stress and MicroRNAs in Vascular Diseases." Int. J. Mol. Sci. 14, no. 9: 17319-17346.