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Int. J. Mol. Sci. 2013, 14(6), 12696-12713; doi:10.3390/ijms140612696
Review

Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins

1,†
, 1,†
, 1,* , 1
, 1
, 2,3
, 4
 and 5,6
Received: 10 April 2013; in revised form: 11 May 2013 / Accepted: 5 June 2013 / Published: 17 June 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: The development of atherosclerosis is a multi-step process, at least in part controlled by the vascular endothelium function. Observations in humans and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. Chronic inflammation is associated with ageing and its related diseases (e.g., atherosclerosis and chronic obstructive pulmonary disease). Recently it has been discovered that Sirtuins (NAD+-dependent deacetylases) represent a pivotal regulator of longevity and health. They appear to have a prominent role in vascular biology and regulate aspects of age-dependent atherosclerosis. Many studies demonstrate that SIRT1 exhibits anti-inflammatory properties in vitro (e.g., fatty acid-induced inflammation), in vivo (e.g., atherosclerosis, sustainment of normal immune function in knock-out mice) and in clinical studies (e.g., patients with chronic obstructive pulmonary disease). Because of a significant reduction of SIRT1 in rodent lungs exposed to cigarette smoke and in lungs of patients with chronic obstructive pulmonary disease (COPD), activation of SIRT1 may be a potential target for chronic obstructive pulmonary disease therapy. We review the inflammatory mechanisms involved in COPD-CVD coexistence and the potential role of SIRT1 in the regulation of these systems.
Keywords: sirtuins; oxidative stress; COPD; cardiovascular diseases; atherosclerosis; inflammation; exercise training; ageing sirtuins; oxidative stress; COPD; cardiovascular diseases; atherosclerosis; inflammation; exercise training; ageing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Corbi, G.; Bianco, A.; Turchiarelli, V.; Cellurale, M.; Fatica, F.; Daniele, A.; Mazzarella, G.; Ferrara, N. Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. Int. J. Mol. Sci. 2013, 14, 12696-12713.

AMA Style

Corbi G, Bianco A, Turchiarelli V, Cellurale M, Fatica F, Daniele A, Mazzarella G, Ferrara N. Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. International Journal of Molecular Sciences. 2013; 14(6):12696-12713.

Chicago/Turabian Style

Corbi, Graziamaria; Bianco, Andrea; Turchiarelli, Viviana; Cellurale, Michele; Fatica, Federica; Daniele, Aurora; Mazzarella, Gennaro; Ferrara, Nicola. 2013. "Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins." Int. J. Mol. Sci. 14, no. 6: 12696-12713.


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