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Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins
Department of Medicine and Health Sciences, University of Molise, via Giovanni Paolo II – Loc. Tappino, 86100 Campobasso, Italy
Department of Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Second University of Naples, via Vivaldi 43, 81100 Caserta, Italy
CEINGE Biotecnologie Avanzate Scarl, via Gaetano Salvatore 486, 80145 Naples, Italy
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, via Leonardo Bianchi, Monaldi Hospital, 80131 Naples, Italy
Translational Medical Sciences – University of Naples "Federico II", via Pansini 5, 80145 Naples, Italy
Salvatore Maugeri" Foundation – Institute of Telese Terme, via Bagni Vecchi 1, 82037 Telese Terme, Italy
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 10 April 2013; in revised form: 11 May 2013 / Accepted: 5 June 2013 / Published: 17 June 2013
Abstract: The development of atherosclerosis is a multi-step process, at least in part controlled by the vascular endothelium function. Observations in humans and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. Chronic inflammation is associated with ageing and its related diseases (e.g., atherosclerosis and chronic obstructive pulmonary disease). Recently it has been discovered that Sirtuins (NAD+-dependent deacetylases) represent a pivotal regulator of longevity and health. They appear to have a prominent role in vascular biology and regulate aspects of age-dependent atherosclerosis. Many studies demonstrate that SIRT1 exhibits anti-inflammatory properties in vitro (e.g., fatty acid-induced inflammation), in vivo (e.g., atherosclerosis, sustainment of normal immune function in knock-out mice) and in clinical studies (e.g., patients with chronic obstructive pulmonary disease). Because of a significant reduction of SIRT1 in rodent lungs exposed to cigarette smoke and in lungs of patients with chronic obstructive pulmonary disease (COPD), activation of SIRT1 may be a potential target for chronic obstructive pulmonary disease therapy. We review the inflammatory mechanisms involved in COPD-CVD coexistence and the potential role of SIRT1 in the regulation of these systems.
Keywords: sirtuins; oxidative stress; COPD; cardiovascular diseases; atherosclerosis; inflammation; exercise training; ageing
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MDPI and ACS Style
Corbi, G.; Bianco, A.; Turchiarelli, V.; Cellurale, M.; Fatica, F.; Daniele, A.; Mazzarella, G.; Ferrara, N. Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. Int. J. Mol. Sci. 2013, 14, 12696-12713.
Corbi G, Bianco A, Turchiarelli V, Cellurale M, Fatica F, Daniele A, Mazzarella G, Ferrara N. Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. International Journal of Molecular Sciences. 2013; 14(6):12696-12713.
Corbi, Graziamaria; Bianco, Andrea; Turchiarelli, Viviana; Cellurale, Michele; Fatica, Federica; Daniele, Aurora; Mazzarella, Gennaro; Ferrara, Nicola. 2013. "Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins." Int. J. Mol. Sci. 14, no. 6: 12696-12713.