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Int. J. Mol. Sci. 2013, 14(10), 19792-19804; doi:10.3390/ijms141019792
Article

Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats

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Received: 19 August 2013; in revised form: 16 September 2013 / Accepted: 17 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: Achyranthes bidentata, a Chinese medicinal herb, is reported to be neuroprotective. However, its role in cardioprotection remains largely unknown. Our present study aimed to investigate the effects of Achyranthes bidentata polypeptides (ABPP) preconditioning on myocardial ischemia/reperfusion (MI/R) injury and to test the possible mechanisms. Rats were treated with ABPP (10 mg/kg/d, i.p.) or saline once daily for one week. Afterward, all the animals were subjected to 30 min of myocardial ischemia followed by 4 h of reperfusion. ABPP preconditioning for one week significantly improved cardiac function following MI/R. Meanwhile, ABPP reduced infarct size, plasma creatine kinase (CK)/lactate dehydrogenase (LDH) activities and myocardial apoptosis at the end of reperfusion in rat hearts. Moreover, ABPP preconditioning significantly inhibited superoxide generation, gp91phox expression, malonaldialdehyde formation and enhanced superoxide dismutase activity in I/R hearts. Furthermore, ABPP treatment inhibited PTEN expression and increased Akt phosphorylation in I/R rat heart. PI3K inhibitor wortmannin blocked Akt activation, and abolished ABPP-stimulated anti-oxidant effect and cardioprotection. Our study demonstrated for the first time that ABPP reduces oxidative stress and exerts cardioprotection against MI/R injury in rats. Inhibition of PTEN and activation of Akt may contribute to the anti-oxidant capacity and cardioprotection of ABPP.
Keywords: Achyranthes bidentata polypeptides; oxidative stress; myocardial ischemia/reperfusion; apoptosis Achyranthes bidentata polypeptides; oxidative stress; myocardial ischemia/reperfusion; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tie, R.; Ji, L.; Nan, Y.; Wang, W.; Liang, X.; Tian, F.; Xing, W.; Zhu, M.; Li, R.; Zhang, H. Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats. Int. J. Mol. Sci. 2013, 14, 19792-19804.

AMA Style

Tie R, Ji L, Nan Y, Wang W, Liang X, Tian F, Xing W, Zhu M, Li R, Zhang H. Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats. International Journal of Molecular Sciences. 2013; 14(10):19792-19804.

Chicago/Turabian Style

Tie, Ru; Ji, Lele; Nan, Ying; Wang, Wenqing; Liang, Xiangyan; Tian, Fei; Xing, Wenjuan; Zhu, Miaozhang; Li, Rong; Zhang, Haifeng. 2013. "Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats." Int. J. Mol. Sci. 14, no. 10: 19792-19804.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert