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Int. J. Mol. Sci. 2013, 14(4), 8062-8072; doi:10.3390/ijms14048062
Article

Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats

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Received: 20 January 2013; in revised form: 1 April 2013 / Accepted: 1 April 2013 / Published: 12 April 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: Endothelial dysfunction participates in the development and progression of salt-sensitive hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). The objectives of this study were to investigate the impact of a high salt diet on the PRMT/ADMA/DDAH (protein arginine methyltransferases; dimethylarginine dimethylaminohydrolase) pathway in Dahl salt-sensitive (DS) rats and SS-13BN consomic (DR) rats, and to explore the mechanisms that regulate ADMA metabolism independent of blood pressure reduction. Plasma levels of nitric oxide (NO) in DS rats given a high salt diet and subjected to intragastric administration of hydralazine (SH + HYD group) were lower than those given a normal salt diet (SN group). There were significant decreases in expression and activity of dimethylarginine dimethylaminohydrolase (DDAH) and endothelial NO synthase (eNOS) in DS rats given a high diet (SH group) in comparison to the SN group. The activity of DDAH and expression of eNOS in the SH + HYD group decreased more significantly than SN group. The mRNA expression of DDAH-1 and DDAH-2 were lowest in the SH group. The results suggest that salt, independent of blood pressure, can affect the PRMT-1/ADMA/DDAH system to a certain degree and lead to endothelial dysfunction in Dahl salt-sensitive rats.
Keywords: endothelial dysfunction; asymmetric dimethylarginine; dimethylarginine; dimethylaminohydrolase; endothelial nitrite oxide synthase; oxidative stress endothelial dysfunction; asymmetric dimethylarginine; dimethylarginine; dimethylaminohydrolase; endothelial nitrite oxide synthase; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cao, Y.; Mu, J.-J.; Fang, Y.; Yuan, Z.-Y.; Liu, F.-Q. Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats. Int. J. Mol. Sci. 2013, 14, 8062-8072.

AMA Style

Cao Y, Mu J-J, Fang Y, Yuan Z-Y, Liu F-Q. Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats. International Journal of Molecular Sciences. 2013; 14(4):8062-8072.

Chicago/Turabian Style

Cao, Yu; Mu, Jian-Jun; Fang, Yuan; Yuan, Zu-Yi; Liu, Fu-Qiang. 2013. "Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats." Int. J. Mol. Sci. 14, no. 4: 8062-8072.


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