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Int. J. Mol. Sci. 2013, 14(12), 23893-23909; doi:10.3390/ijms141223893
Review

Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases

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Received: 18 September 2013; in revised form: 11 November 2013 / Accepted: 21 November 2013 / Published: 9 December 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10 (CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ10 is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. A Low-T3 syndrome is a condition observed in several chronic diseases: it is considered an adaptation mechanism, where there is a reduction in pro-hormone T4 conversion. Low T3-Syndrome is not usually considered to be corrected with replacement therapy. We review the role of thyroid hormones in regulation of antioxidant systems, also presenting data on total antioxidant capacity and Coenzyme Q10. Published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases; our data could support the rationale of replacement therapy in low-T3 conditions.
Keywords: oxidative stress; coenzyme Q10; total antioxidant capacity; thyroid hormones; “low-T3” syndrome oxidative stress; coenzyme Q10; total antioxidant capacity; thyroid hormones; “low-T3” syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mancini, A.; Raimondo, S.; Di Segni, C.; Persano, M.; Gadotti, G.; Silvestrini, A.; Festa, R.; Tiano, L.; Pontecorvi, A.; Meucci, E. Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases. Int. J. Mol. Sci. 2013, 14, 23893-23909.

AMA Style

Mancini A, Raimondo S, Di Segni C, Persano M, Gadotti G, Silvestrini A, Festa R, Tiano L, Pontecorvi A, Meucci E. Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases. International Journal of Molecular Sciences. 2013; 14(12):23893-23909.

Chicago/Turabian Style

Mancini, Antonio; Raimondo, Sebastiano; Di Segni, Chantal; Persano, Mariasara; Gadotti, Giovanni; Silvestrini, Andrea; Festa, Roberto; Tiano, Luca; Pontecorvi, Alfredo; Meucci, Elisabetta. 2013. "Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases." Int. J. Mol. Sci. 14, no. 12: 23893-23909.


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