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Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases
Department of Medical Sciences, Division of Endocrinology, Catholic University, Rome 00168, Italy;
Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome 00168, Italy
Department of Clinical and Molecular Science, Polytechnic University of the Marche, Ancona 60100, Italy
Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona 60100, Italy
* Author to whom correspondence should be addressed.
Received: 18 September 2013; in revised form: 11 November 2013 / Accepted: 21 November 2013 / Published: 9 December 2013
Abstract: In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10 (CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ10 is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. A Low-T3 syndrome is a condition observed in several chronic diseases: it is considered an adaptation mechanism, where there is a reduction in pro-hormone T4 conversion. Low T3-Syndrome is not usually considered to be corrected with replacement therapy. We review the role of thyroid hormones in regulation of antioxidant systems, also presenting data on total antioxidant capacity and Coenzyme Q10. Published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases; our data could support the rationale of replacement therapy in low-T3 conditions.
Keywords: oxidative stress; coenzyme Q10; total antioxidant capacity; thyroid hormones; “low-T3” syndrome
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MDPI and ACS Style
Mancini, A.; Raimondo, S.; Di Segni, C.; Persano, M.; Gadotti, G.; Silvestrini, A.; Festa, R.; Tiano, L.; Pontecorvi, A.; Meucci, E. Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases. Int. J. Mol. Sci. 2013, 14, 23893-23909.
Mancini A, Raimondo S, Di Segni C, Persano M, Gadotti G, Silvestrini A, Festa R, Tiano L, Pontecorvi A, Meucci E. Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases. International Journal of Molecular Sciences. 2013; 14(12):23893-23909.
Mancini, Antonio; Raimondo, Sebastiano; Di Segni, Chantal; Persano, Mariasara; Gadotti, Giovanni; Silvestrini, Andrea; Festa, Roberto; Tiano, Luca; Pontecorvi, Alfredo; Meucci, Elisabetta. 2013. "Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases." Int. J. Mol. Sci. 14, no. 12: 23893-23909.