Int. J. Mol. Sci. 2013, 14(8), 16258-16279; doi:10.3390/ijms140816258
Review

The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair

1,2,* email, 2,3,4email, 2,4,5email, 3,6email and 2,4,6,* email
Received: 30 May 2013; in revised form: 23 July 2013 / Accepted: 30 July 2013 / Published: 6 August 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from the circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration. This paper reviews the recent findings on the role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair following ischemic heart disease, particularly acute MI and focuses specifically on mesenchymal, muscle and blood-vessel-derived stem cells due to their antioxidant and immunomodulatory properties.
Keywords: stem cells; myocardial infarction; oxidative stress; inflammation; immune system; cardiac repair
PDF Full-text Download PDF Full-Text [277 KB, uploaded 19 June 2014 05:03 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Saparov, A.; Chen, C.-W.; Beckman, S.A.; Wang, Y.; Huard, J. The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair. Int. J. Mol. Sci. 2013, 14, 16258-16279.

AMA Style

Saparov A, Chen C-W, Beckman SA, Wang Y, Huard J. The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair. International Journal of Molecular Sciences. 2013; 14(8):16258-16279.

Chicago/Turabian Style

Saparov, Arman; Chen, Chien-Wen; Beckman, Sarah A.; Wang, Yadong; Huard, Johnny. 2013. "The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair." Int. J. Mol. Sci. 14, no. 8: 16258-16279.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert