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Int. J. Mol. Sci. 2013, 14(11), 21525-21550; doi:10.3390/ijms141121525
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Oxidative Stress in Diabetes: Implications for Vascular and Other Complications

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Received: 22 August 2013 / Revised: 14 October 2013 / Accepted: 18 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract

In recent decades, oxidative stress has become a focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence shows that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure. Based on these studies, an emerging concept is that oxidative stress is the “final common pathway” through which the risk factors for several diseases exert their deleterious effects. Oxidative stress causes a complex dysregulation of cell metabolism and cell–cell homeostasis; in particular, oxidative stress plays a key role in the pathogenesis of insulin resistance and β-cell dysfunction. These are the two most relevant mechanisms in the pathophysiology of type 2 diabetes and its vascular complications, the leading cause of death in diabetic patients.
Keywords: oxidative stress; reactive oxidative species; diabetes mellitus; insulin resistance; β-cell dysfunction; vascular complications oxidative stress; reactive oxidative species; diabetes mellitus; insulin resistance; β-cell dysfunction; vascular complications
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pitocco, D.; Tesauro, M.; Alessandro, R.; Ghirlanda, G.; Cardillo, C. Oxidative Stress in Diabetes: Implications for Vascular and Other Complications. Int. J. Mol. Sci. 2013, 14, 21525-21550.

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