Int. J. Mol. Sci. 2013, 14(4), 6903-6919; doi:10.3390/ijms14046903
Article

Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption

1 Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain 2 Department of Nutrition and Bromatology, The Complutense University of Madrid, Madrid 28040, Spain 3 CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, Madrid 29029, Spain
* Author to whom correspondence should be addressed.
Received: 30 January 2013; in revised form: 8 March 2013 / Accepted: 19 March 2013 / Published: 27 March 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
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Abstract: Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia.
Keywords: metabolic syndrome; hyperglycemia; oxidative stress; TAC; fruit

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MDPI and ACS Style

de la Iglesia, R.; Lopez-Legarrea, P.; Celada, P.; Sánchez-Muniz, F.J.; Martinez, J.A.; Zulet, M.A. Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption. Int. J. Mol. Sci. 2013, 14, 6903-6919.

AMA Style

de la Iglesia R, Lopez-Legarrea P, Celada P, Sánchez-Muniz FJ, Martinez JA, Zulet MA. Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption. International Journal of Molecular Sciences. 2013; 14(4):6903-6919.

Chicago/Turabian Style

de la Iglesia, Rocio; Lopez-Legarrea, Patricia; Celada, Paloma; Sánchez-Muniz, Francisco J.; Martinez, J. A.; Zulet, M. A. 2013. "Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption." Int. J. Mol. Sci. 14, no. 4: 6903-6919.

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