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Keywords = water–1,6-dichlorohexane

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15 pages, 3948 KB

Open AccessArticle

Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

by Eissa Mohamed Almbrok, Nor Azah Yusof, Jaafar Abdullah and Ruzniza Mohd Zawawi

Chemosensors 2021, 9(1), 15; https://doi.org/10.3390/chemosensors9010015 - 15 Jan 2021

Cited by 4 | Viewed by 3195

Abstract

Electrochemical characterization and detection of protonated dibucaine (

{DIC}^{+}

Electrochemical characterization and detection of protonated dibucaine (

{DIC}^{+}

) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of

{DIC}^{+},

resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM. Full article

(This article belongs to the Section Electrochemical Devices and Sensors)

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16 pages, 4129 KB

Open AccessArticle

Electrochemical Behavior and Detection of Diclofenac at a Microporous Si₃N₄ Membrane Modified Water–1,6-dichlorohexane Interface System

by Eissa Mohamed Almbrok, Nor Azah Yusof, Jaafar Abdullah and Ruzniza Mohd Zawawi

Chemosensors 2020, 8(1), 11; https://doi.org/10.3390/chemosensors8010011 - 5 Feb 2020

Cited by 13 | Viewed by 4823

Abstract

The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac (

{DCF}^{-}

), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic [...] Read more.

{DCF}^{-}

), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic treatment in common use in biomedical applications, were also investigated across microporous silicon nitride-modified liquid interface. Thus, some thermodynamic variables for

{DCF}^{-}

, such as the standard Gibbs energy of transfer, the standard transfer potential and lipophilicity were estimated. Furthermore, the influence of possible interfering substances (ascorbic acid, sugar, amino acid, urea, and metal ions) on the detection of

{DCF}^{-}

was investigated. An electrochemical DCF sensor is investigated using differential pulse voltammetry (DPV) as the quantification technique, a linear range of 8–56 µM and a limit of detection of 1.5 µM was possible due to the miniaturized interfaces formed within silicon nitride. Full article

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