Search Results (32)

Background: The reproducibility of research findings continues to be a challenge in many fields, including neurosciences. It is now required that biological variables such as sex and age be considered in preclinical and clinical research. Rodents are frequently used to model clinical conditions; however, litter information is rarely presented. Some studies utilize entire litters with each animal treated as an independent sample, while others equally assign animals from each litter to different groups/treatments, and others use averaged data. These methods can yield different results. Methods: This study used different analysis methods to evaluate embryo and placenta weights from E17.5 acid-sensing ion channel 2a (ASIC2a) mice with or without seizure exposure. Results: When each embryo was treated as an individual sample, fetal and placental weight significantly differed following seizures in the ASIC2a heterozygous (+/−) and homozygous (−/−) groups. Differences in fetal weight were driven by females in the ASIC2a+/− group and both sexes in the ASIC2a−/− group. These differences were lost when an average per sex/genotype/litter was used. There was no difference in placental weight when treated individually; however, female ASIC2a−/− placentas weighed less following seizures. This difference was lost with averaged data. ASIC2a−/− fetuses from −/− dams had reduced weights post-seizure exposure. Position on the uterine horn influenced embryo and placental weight. Conclusions: Our results indicate that using full litters analyzed as individual data points should be avoided, as it can lead to Type I errors. Furthermore, studies should account for litter effects and be transparent in their methods and results. Full article

Our research examines the dynamics of policy implementation in forest fire management and how local governments in Indonesia can successfully implement these policies. There are two main issues: first, the extent to which forest fire management practices are collaborative, which we assess by examining whether government implementation has focused on developing integrated forest fire management policies represented through collaborative networks. Second, we consider whether and how governments and other competing stakeholders move from conflict to collaboration to enable policy implementation. This research explores whether and how collaborative management can provide a foundation for successful forest fire management, particularly in Riau Province, Sumatra, Indonesia, an area that has experienced significant forest fires and expansion of plantations and oil palm industries. Data were collected through in-depth interviews and observations. We revealed a lack of coordination among local, central, and other stakeholders, which might result in policy “tyranny”. In order to effectively reduce the number of fires, the government needs to empower those responsible for fire prevention through law and policy. However, because forest fire management is inherently top-down and often excludes lower levels of bureaucracy, collaborative management remains challenging. Full article

This article aims to examine how social media has changed the way human beings perceive themselves, exerting a tyrannical influence over personal image, leading people to aesthetic procedures and surgeries. It happens through the imitative dimension of human beings. Social media has created idealized world(s) where people see images of faces, bodies, and lives they perceive as perfect, leading them to question such aspects about themselves in comparison to the presented ideal(s). These idealized world(s) foster a contemporary Gnosticism, where people start seeing their own faces and bodies as flawed or inferior compared to these idealized images. This gives rise to a tyranny of social media over personal image, reshaping how individuals view themselves and pressuring them to conform to these idealized world(s). Theology has a mission to help people appreciate the beauty and goodness of real bodies and guide them toward the fruition of being bodily beings. Full article

The history of religions during the nineteenth and early twentieth centuries has been closely tied to the classification of Indigenous religions. However, recent scholarship in the field of religion has increasingly drawn on the work of subaltern and postcolonial historiography as a way of disrupting the European canon and dislodging Indigenous and non-western ways of knowing and being from the tyranny of the classical taxonomies of religion. Recent approaches to religious diversity have been challenged for reproducing imperial hierarchies of religion—assuming an accommodationist approach to Indigenous religions while also rendering invisible the internal diversity, fluidity, and adaptive orientations within Indigenous religions. In this paper, I contend that in the postcolonial context, Indigenous religions uncouple themselves from traditional taxonomies of religion, and, in particular, I propose religious complexity as a suitable framework and approach for accounting, contending with, and reporting on religious change in postcolonial South Africa. I explore questions about how to account for, ‘classify’, or ‘measure’ change related to everyday African Indigenous religious efforts and practices in the aftermath of and in response to colonialism, where conventional ideas about religious authority and affinity are displaced by Indigenous practices that can variously be described as simultaneously vital, viral, or feral. Full article

In Romans 5, Paul says that prior to law “sin is not counted” (v. 13), and that upon law’s arrival, “the trespass increased” (v. 20). For most interpreters, the law that counted sin and increased the trespass is the law that God revealed to Israel at Sinai. Origen of Alexandria offered significant exegetical objections to this reading and proposed that natural law is in view. I modify Origen’s proposal to align Paul with the early Jewish tradition of Adam’s law, and I argue that “law” in vv. 13a and 20 refers to law’s arrival to Adam. Romans 5:12–21 is Paul’s re-telling of Scripture and chronicles Sin and Death achieving their global reigns. Understood this way, vv. 12–14 and 20–21 tell us what transpired when God’s law came to Adam: Sin and Death united, and they launched and secured their cosmic tyranny. This is Sin and Death’s origin story. Full article

Based on social exchange theory, social psychology theories, and despotic leadership theory, this study explored the impact of petty tyranny on employee turnover intentions. Specifically, the authors examined the mediating effect of toxic workplace environments through emotional exhaustion on this relationship among academicians. The authors surveyed 421 employees using a five-point Likert scale across six universities in Lahore, Pakistan and employed a time-lag research design. Partial least squares structural equation modeling (PLS-SEM) and artificial neural network (ANN) analyses, including performance comparisons of various algorithms, were used to test the relationships among the variables. The analysis results of the study suggested that petty tyranny does not significantly and directly contribute to employee turnover intentions; however, this relationship is positively and significantly mediated by toxic workplace environments and emotional exhaustion. The results indicated that toxic workplace environments and emotional exhaustion also have a direct effect on employee turnover intentions. A serial full mediation was found between petty tyranny and turnover intentions, mediated through a toxic workplace environment and emotional exhaustion. Similarly, results from the performance comparison of various algorithms reveal trade-offs between precision, recall, and processing time, with ZeroR and Stacking REP Tree emerging as the most effective in terms of overall model accuracy. This study contributes to the literature by examining petty tyranny, workplace environment, and emotional exhaustion, highlighting the need to address tyrannical behavior to improve employee retention in academic organizations. Our study offers valuable practical implications, emphasizing addressing these issues to reduce turnover in academic organizations. Our study also provides recommendations for future research directions. Full article

Some philosophers argue that animals should be included in the democratic system, with people acting as their representatives in voting on issues that concern them. This article contends that, while animals’ rights are fundamentally important, granting people rights to represent animals in democratic processes may lead to the opposite of what we want. Or worse, it may put animals’ interests and rights at significant risk. If animals’ rights are basic and straightforward, as proponents of this proposal assume, then deliberation is either redundant or dangerous in safeguarding the interests of animals. Full article

The worldwide launch of neoliberalism ushered everyone into an atomized society. Neoliberalism transforms Homo sapiens into Homo economicus, a narcissistic self-entrepreneur that positions their body as a factory, skills as resources, and earnings as products while relying less on others. Such atomization of individuals undermines the community. Following the Cartesian moment, enlightenment, and postmodernism’s later wave, the world is disenchanted, deprived of unity in the form of community fragmentation. Foucault offered a Greco–Roman philosophical remedy for contemporary society, focusing on the formulation of ‘Spiritual-Corporality’ through the practice of care of the self. Foucault believed the one who takes good care of himself is often self-assured of his ability, expectations, and missions in relationships with others, he does not resort to tyranny in those relationships, giving him an ethical advantage in caring for his family and fellow citizens. If everyone strives to take care of themselves, the city-state will prosper. However, Foucault relied on Stoic philosophy over other ancient schools and failed to provide concrete practices on how to bind ourselves with others through care of the self. In partial agreement with Foucault, the present study chooses Hadot’s spiritual exercise as a more accurate terminology to justify Greco–Roman philosophies’ affordance to contemporary social unification. After reviewing the philosophies of Aristotle, the Stoics, and Epicurus, the present study selected the spiritual exercises of ‘hitting the mean as deliberation’, ‘reframing of self’, and ‘thinking outside the box’ as suitable practices for community flourishing. Full article

With Great House (2010), Nicole Krauss offers a choral novel that interweaves the lives of several characters loosely connected by a huge, wooden desk that one of them relentlessly chases around the world. A possible symbol of the memory of the Second World War Jewish genocide transmitted to younger generations, the desk powerfully materializes transmission in its potentially traumatic, obsessional, and violent dimensions. This essay deals with the way first- and second-generation women, in the novel, develop ingenious, creative but also uncompromising responses to the inescapable duty of remembrance. While the dominating male characters freeze memory in timeless, petrified representations, these female writers expose its terrible necessity while hiding nothing of the damages memory causes to witnesses and descendants. They claim a right of inventory and use the desk as an echo-chamber reflecting both the suffering voices of children and the dark presence of defaulting fathers and failing mothers, thus allowing for a new generation to be born with a more bearable heritage. Full article

The article examines perceptions of tyranny in Melito’s On Pascha and Apology, both written under Marcus Aurelius (161–180). This is the first systematic treatment of a key theme in Melito, approached not only from a theological perspective but also in the context of the Second Sophistic and Roman political developments. By proposing a more precise dating for On Pascha, we trace the development and consistency of Melito’s thought and arguments in regard to the relationship between Roman Empire and Christian communities in Asia Minor during the second half of the second century CE. Full article

This article presents a case that former President of the United States Donald Trump was a tyrant-like leader in the mold of the tyrant in Plato’s Republic. While he does not perfectly embody the tyrant as presented in the Republic, he captures its core feature. Like the tyrant, Trump is driven by unregulated desires that reflect what Plato describes as an extreme freedom that underlies and threatens democratic regimes. Extreme freedom is manifested in Trump’s disregard for social and legal norms, which mirrors the lawlessness of the tyrant. The people, in turn, interpret that posture as a mark of authenticity. Understanding Trump’s appeal in the United States helps alert friends of democracy to the possible rise of tyrant-like figures. In closing, and as a way of remedying the harm done by the tyrannical soul, the article recommends that society help temper tyrant-like passions in the people through a rededication to civic equality. Full article

Shakespeare’s Macbeth has traveled a long way from its original milieu. This paper takes three major 21st-century Indian adaptions of Macbeth as its primary texts. The city of Mumbai in the west in Maqbool, an imaginary coastal Bengal village in the east in Mandaar, and the suburbs of Kerala in Joji in the south of the subcontinent become sites of “creative mistranslations” of the play. In this paper, we take the ambiguity that Shakespeare’s witches evoke in the early 17th-century Scottish world as a point of entry and consider how that ambiguity is translated in its 21st-century Indian on-screen adaptations. Cutting across spaciotemporal boundaries, the witches remain a source of utmost significance through their presence/absence in the adaptations discussed. In Maqbool, Shakespeare’s heath-hags become male upper-caste law-keepers, representing the tyrannies of state machinery. Mandaar’s witches become direct agents of Mandaar’s annihilation at the end after occupying a deceptively marginal position in the sleazy world of Gailpur. In an apparent departure, Joji’s world is shorn of witches, making him appear as the sole perpetrator of the destruction in a fiercely patriarchal family. A closer reading, however, reveals the ominous presence of some insidious power that defies the control of any individual. The compass that directs Macbeth and its adaptations, from the West to the East, from 1606 to date, is the fatalism that the witches weave, in their seeming absence as well as in their portentous presence. We cannot help but consider them as yardsticks in any tragedy that deals with the age-old dilemma of predestination and free will. Full article

Resilience thinking provides valuable insights into the dynamics of complex adaptive systems. To achieve resilience in urban systems, it can be fruitful to delve into the intricacies of resilience processes. This paper theorizes about how the specific characteristics of resilient systems can be integrated into the spatial design of cities. Emphasizing the importance of the built form and spatial systems in maintaining order within urban processes, we focus on how adaptive renewal cycles can be applied to various systems and dimensions where urban change, adaptation, and renewal occur. The paper identifies key resilient system characteristics applicable to urban spatial form and contextualizes urban renewal within the adaptive renewal cycle—a framework originally developed to capture temporal and spatial ecosystem dynamics. We integrate insights within ‘space syntax theory’, theorizing about how cities renew themselves over space and time. We discuss instances of ‘compressed resilience’ and the challenges posed by the ‘tyranny of small decisions’ in urban planning and development. In conclusion, we identify future research directions in the theory of spatial morphology and resilient urban systems, emphasizing the need for a deeper understanding of the interplay between urban processes, urban form, resilience, and adaptive renewal. Full article

In On Revolution, Hannah Arendt makes the case that a constitution must account for the need of the human person to participate in the building of society, both as a primordial and continual action of founding. This paper draws on Arendt’s insight on the relationship between privacy and the notion of property, both of which the constitution must protect, as it is dependent on those notions. Property in its fullest sense is the means by which a person interacts with others and establishes a society. Particularly important for this notion of engagement are the concepts of shame and the love of goodness. The actor emerges from the private sphere to interact with others on the strength of the secrecy and confidentiality of her intimate, private relationships. Property is therefore essential to human flourishing and happiness. Following this, the activity of constructing the public forum on the basis of the private is an important feature of Arendt’s constitutionalism. Human Action showers third-party esteem on the actor’s family and friends, binding them to the constitutional structure and strengthening familial relationships and social cohesion. Full article

The Qur’anic term and principle of “qist”—generally defined as fairness, equity, and giving each his/her due share—occurs twenty-two times and forms a particular intentional discourse against social and economic privilege and against power in its various dimensions. These occurrences, their contexts, and fields of meaning demonstrate its distinctive place within the Qur’anic moral worldview, at the nexus between private virtue ethics and collective praxis. Qist is presented not merely as an abstract ideal, but as a specific, concrete social and economic goal for the marginalized and disempowered of any community. Especially in the domains of gender relations, poverty conditions, and authorial power, the divine injunction for applying equality in lived contexts becomes a call for liberation from “zulm” (injustice) and “taghut” (false deities). Can the examination of this concept and its affiliates form the basis for a scriptural theorization on an Islamic theology of social and economic justice, of resistance to tyranny and unjust constructions of privilege and superiority? Towards an answer to this inquiry, one can argue that qist directs attention to the practical ways of applying the overarching, comprehensive value of shari’ah, al-‘adl (justice), as well as to its defining features of collectivity and distributiveness. Full article