Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
24 pages, 6846 KB  
Review
Noncanonical Reactions of Flavoenzymes
by Pablo Sobrado
Int. J. Mol. Sci. 2012, 13(11), 14219-14242; https://doi.org/10.3390/ijms131114219 - 5 Nov 2012
Cited by 29 | Viewed by 12329
Abstract
Enzymes containing flavin cofactors are predominantly involved in redox reactions in numerous cellular processes where the protein environment modulates the chemical reactivity of the flavin to either transfer one or two electrons. Some flavoenzymes catalyze reactions with no net redox change. In these [...] Read more.
Enzymes containing flavin cofactors are predominantly involved in redox reactions in numerous cellular processes where the protein environment modulates the chemical reactivity of the flavin to either transfer one or two electrons. Some flavoenzymes catalyze reactions with no net redox change. In these reactions, the protein environment modulates the reactivity of the flavin to perform novel chemistries. Recent mechanistic and structural data supporting novel flavin functionalities in reactions catalyzed by chorismate synthase, type II isopentenyl diphosphate isomerase, UDP-galactopyranose mutase, and alkyl-dihydroxyacetonephosphate synthase are presented in this review. In these enzymes, the flavin plays either a direct role in acid/base reactions or as a nucleophile or electrophile. In addition, the flavin cofactor is proposed to function as a “molecular scaffold” in the formation of UDP-galactofuranose and alkyl-dihydroxyacetonephosphate by forming a covalent adduct with reaction intermediates. Full article
(This article belongs to the Special Issue Flavins)
Show Figures

Graphical abstract

Back to TopTop