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Article

1 Citations

1,617 Views

19 Pages

Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties

Sarah Sarwar,
Nadia Sarwar,
Haleema Ali,
Rafiullah,
Rasool Khan,
Ajaz Ahmad,
Amin Ullah,
Ho Soonmin and
Nazif Ullah

Biomedicines2025, 13(1), 93;https://doi.org/10.3390/biomedicines13010093

3 January 2025

Background/Objectives: Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with L...

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Article

17 Citations

4,535 Views

19 Pages

Hetero-Diels-Alder Reactions of In Situ-Generated Azoalkenes with Thioketones; Experimental and Theoretical Studies

Grzegorz Mlostoń,
Katarzyna Urbaniak,
Malwina Sobiecka,
Heinz Heimgartner,
Ernst-Ulrich Würthwein,
Reinhold Zimmer,
Dieter Lentz and
Hans-Ulrich Reissig

Molecules2021, 26(9), 2544;https://doi.org/10.3390/molecules26092544

27 April 2021

The hetero-Diels-Alder reactions of in situ-generated azoalkenes with thioketones were shown to offer a straightforward method for an efficient and regioselective synthesis of scarcely known N-substituted 1,3,4-thiadiazine derivatives. The scope of t...

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Article

1,491 Views

17 Pages

Evaluation of the Ameliorative Potential of 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione against Scopolamine-Induced Alzheimer’s Disease

Shagufta,
Gowhar Ali,
Adnan Khan,
Abdur Rasheed,
Farah Deeba,
Rahim Ullah,
Muhammad Shahid,
Haleema Ali,
Rasool Khan and
Naveed Sharif
+ 1 author

Int. J. Mol. Sci.2024, 25(16), 9104;https://doi.org/10.3390/ijms25169104

22 August 2024

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, marked by cognitive impairment. Currently, the available treatment provides only symptomatic relief and there is a great need to design and formulate new drugs to stabilize...

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Article

3 Citations

2,869 Views

13 Pages

Serological Cross-Reaction between Six Thiadiazine by Indirect ELISA Test and Their Antimicrobial Activity

Mishell Ortiz,
Hortensia Rodríguez,
Elisabetta Lucci,
Julieta Coro,
Beatriz Pernía,
Abigail Montero-Calderon,
Francisco Javier Tingo-Jácome,
Leslie Espinoza and
Lilian M. Spencer

Methods Protoc.2023, 6(2), 37;https://doi.org/10.3390/mps6020037

3 April 2023

Malaria is a parasitic infection caused by a protozoon of the genus Plasmodium, transmitted to humans by female biting mosquitoes of the genus Anopheles. Chloroquine and its derivates have caused the parasite to develop drug resistance in endemic are...

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Article

4 Citations

1,176 Views

20 Pages

Tetrahydro-2H-1,3,5- thiadiazin-t-thione Derivatives of The optical Isomers of Phenylalanine, Synthesis, Comparative Stability Study and Antifungal Activity

Aboul-Fadl Tarek and
Osman Mahrous

Sci. Pharm.2002, 70(4), 359-378;https://doi.org/10.3797/scipharm.aut-02-35

10 December 2002

In order to investigate the effect of the optical properties of the 5-substituent on the stability and the antihngal activity of tetrahydro-2H-1,3,5-thiadizine-2-thione (THTT) moiety, optical isomers and racemic mixture of phenylalanine were incorpor...

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