Search Results (2)

Nonsteroidal anti-inflammatory drug-based therapies are the cause of 20–30% cases of gastric lesions in chronic users worldwide. Co-medication with omeprazole (OMP) is the most commonly used option to prevent these lesions, although this carries risks of its own; thus, alternatives are being explored, such as dietary antioxidant therapies. The objective of this study was to evaluate the gastroprotective activity of quinoa (Chenopodium quinoa Willd.) on ibuprofen (IBP)-induced gastric ulcers in a rat model. Quinoa cookies were formulated with heat-treated quinoa using microwave radiation. The intestinal bioaccessibility of phenols and flavonoids, and the antioxidant activity of microwaved quinoa cookies (MQCs) were notably higher than quinoa cookies without thermal treatment (RQCs): 132% TPC, 52% TFC, 1564% TEAC vs. 67% TPC, 24% TFC, and 958% TEAC, respectively. Basal diets were supplemented with MQCs (20%) and quercetin (Q, 0.20%) as a reference flavonoid and administered for 30 days. Gastric lesions were induced by intragastric IBP doses, with OMP treatment as a positive control. Gastric damage index (macroscopic study), histological score (microscopic study), and plasma antioxidant enzyme activity (SOD and CAT) were evaluated. Macroscopic results showed that the addition of MQCs, Q, and OMP decreased the gastric damage index (GDI) by 50%, 40%, and 3%, respectively, as compared to IBP (GDI 100%). Histological analyses showed neutrophil infiltration and congested blood vessels in IBP-treated tissues; in contrast, the experimental diet groups showed lower infiltration for MQC > OMP > Q, respectively. A significant increase in SOD and CAT enzyme activity was observed in the MQC and Q groups as compared to the IBP group. We conclude that a reduction in the GDI and histological score was observed in IBP-induced murine models fed diets containing 20% MQC and 0.20% Q, demonstrating a preventive gastroprotective effect. Full article

In modern times, the design and optimization of different actuator systems for controlling a high-precision position control system represent a popular interdisciplinary research area. Initially, only single-stage actuator systems were used to control most of the motion control applications. Currently, dual-stage actuation systems are widely applied to high-precision position control systems such as hard disk drive (HDD) servo systems. In the dual-stage system, a voice coil motor (VCM) actuator is used as the primary stage and a piezoelectric micro-actuator is applied as the secondary stage. However, a dual-stage control architecture does not show significant performance improvements to achieve the next-generation high-capacity HDD servo system. Research continues on how to fabricate a tertiary actuator for a triple-stage HDD servo system. A thermal positioning controller (TPC) actuator is considered promising as the tertiary stage. The triple-stage system aims to achieve greater bandwidth, track density, and disk speed, with minimum sensitivity and greater error minimization. In this work, these three actuation systems with different combinations of proportional plus integral (PI), proportional plus derivative (PD), and proportional plus integral plus derivative (PID) controller, lag-lead controller, lag filter, and inverse lead plus a PI controller were designed and analyzed through simulation to achieve high-precision positioning. The comparative analyses were done on the MATLAB/Simulink simulation platform. Full article